Efficacy comparison of lyophilised black raspberries and combination of celecoxib and PBIT in prevention of carcinogen-induced oesophageal cancer in rats.
Efficacy comparison of lyophilised black raspberries and combination of celecoxib and PBIT in prevention of carcinogen-induced oesophageal cancer in rats.
复制标题
冻干黑树莓与塞来昔布和 PBIT 联合预防大鼠食道癌的功效比较。
DOI：
10.1016/j.jff.2016.08.044
复制
发表时间：
2016
影响因子：
5.6
通讯作者：
Chen,Tong
中科院分区：
文献类型：
--
作者：
Shi,Ni;Riedl,KennethM;Schwartz,StevenJ;Zhang,Xiaoli;Clinton,StevenK;Chen,Tong
本研究的目的是比较冻干黑树莓与选择性环氧合酶-2(COX-2)抑制剂塞来昔布和选择性诱导型一氧化氮合酶(S′-1，4-phenylene-bis(1，2-ethanediyl)bis-isothiourea)抑制剂PBIT合用抑制致癌物诱导的大鼠食管鳞癌的疗效和作用机制。我们的数据表明，与服用塞来昔布 + PBIT的动物相比，服用BRB的动物的肿瘤多样性和食道癌前病变的组织学分级都有所降低。机制研究表明，BRB及其主要花色苷抑制细胞增殖和致癌信号转导。我们的研究结果表明，饮食BRB在预防食道癌方面优于两种药物的联合应用。这些观察结果表明，使用BRB食品产品进行的翻译研究在人类食道癌预防中的潜在价值，特别是那些具有高危癌前病变的人。
The objective of this study was to compare the efficacy and mechanism of lyophilised black raspberries (BRB) versus the combination of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, andS,S′-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBIT), a selective inducible nitric oxide synthase (iNOS) inhibitor in inhibition of carcinogen-induced oesophageal squamous cell carcinoma in rats. Our data indicated that tumour multiplicity and histologic grade of oesophageal precancerous lesions were reduced in animals fed BRB compared to those fed celecoxib + PBIT. The mechanistic studies showed that BRB and its major anthocyanin suppressed cell proliferation and oncogenic signalling. Our findings demonstrated that dietary BRB is superior to the combination of two pharmaceutical drugs in oesophageal cancer prevention. These observations suggest the potential value of translational studies using BRB food products for oesophageal cancer prevention in humans, particularly those with high-risk premalignant lesions.