Vitamin D and skin cancer: A meta-analysis
Vitamin D and skin cancer: A meta-analysis
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DOI：
10.1016/j.ejca.2008.10.003
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发表时间：
2009-03-01
影响因子：
8.4
通讯作者：
Testori, Alessandro
中科院分区：
文献类型：
--
作者：
Gandini, Sara;Raimondi, Sara;Testori, Alessandro
对文献进行了全面的书目检索，以确定有关皮肤恶性黑色素瘤 (CMM) 和非黑色素瘤皮肤癌 (NMSC)、维生素 D 受体 (VDR) 多态性、维生素 D 摄入量和 25(OH)D 血清水平的研究。找到并提取了两种多态性 FokI 和 BsmI 以及维生素 D 摄入量的完全调整的风险估计。荟萃分析中纳入了 10 项研究，总共 6805 例皮肤癌病例。我们发现这两种多态性与 CMM 存在关联。 CMM 研究的总体相对风险 (SRR) 为： Ff 和 ff 与 FokI 野生型相比，分别为 1.21 (1.03-1.42) 和 1.21 (0.95-1.54)。随着 NMSC 的纳入，ff 与野生型的 SRR 变得显着。 CMM 研究的 SRR 分别为：Bb 和 BB 与 BsmI 野生型相比，SRR 分别为 0.78 (0.65-0.92) 和 0.75 (0.59-0.95)。也有轻微迹象表明膳食维生素 D 在 CMM 发展中的作用。 总之，这项荟萃分析表明 VDR FokI 和 BsmI 多态性可能具有重要作用。 CMM 和 NMSC 风险。与维生素 D 摄入量的关系尚不清楚，进一步的研究可能有助于阐明饮食的作用。 (C) 2008 Elsevier Ltd. 保留所有权利。
A comprehensive bibliographic search of the literature was conducted to identify studies on Cutaneous Malignant Melanoma (CMM) and non-melanoma skin cancer (NMSC), Vitamin D receptor (VDR) polymorphisms, Vitamin D intake and 25(OH)D serum levels. Fully adjusted risk estimates were found and extracted for the two polymorphisms FokI and BsmI and Vitamin D intake. Ten studies were included in the meta-analysis, with a total of 6805 skin cancer cases.We found an association with CMM for both polymorphisms. The summary relative risks (SRR) for the studies on CMM were: 1.21 (1.03-1.42) and 1.21 (0.95-1.54) for the Ff and ff versus wild-type of FokI, respectively The SRR for ff versus wild-type became significant with the inclusion of NMSC. The SRR for the studies on CMM were: 0.78 (0.65-0.92) and 0.75 (0.59-0.95) for the Bb and BB versus wild-type of BsmI, respectively There is also a slight indication of a role of dietary Vitamin D in CMM development.In conclusion, this meta-analysis suggests a possible significant role of VDR FokI and BsmI polymorphism. in CMM and NMSC risk. The association with Vitamin D intake is less clear and further studies could be useful to clarify the role of diet. (C) 2008 Elsevier Ltd. All rights reserved.