A hierarchy of temporal receptive windows in human cortex
A hierarchy of temporal receptive windows in human cortex
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DOI：
10.1523/jneurosci.5487-07.2008
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发表时间：
2008-03-05
影响因子：
5.3
通讯作者：
Rubin, Nava
中科院分区：
文献类型：
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作者：
Hasson, Uri;Yang, Eunice;Rubin, Nava
现实世界的事件在不同的时间尺度上展开，因此，认知和神经元过程也必须在不同的时间尺度上发生。我们提出了一种新的程序，识别大脑区域响应感官信息积累在不同的时间尺度。当观察者观看无声电影时，我们测量了他们的功能性磁共振成像活动。早期视觉区（如初级视觉皮层和运动敏感区MT+）表现出高的反应可靠性，而与颞叶结构的破坏无关。相比之下，包括颞上沟（STS）、楔前叶、后外侧沟（LS）、颞顶叶交界处（TPJ）和额视野（FEF）在内的几个高级脑区反应的可靠性受到长时间积累的信息的影响。这些区域对重复的正向呈现表现出高度可重复性的反应，但对向后呈现或分段打乱呈现则没有。此外，这些区域表现出明显的时间特征差异，与STS和楔前叶相比，LS、TPJ和FEF的反应依赖于更长时间（类似于36秒）积累的信息。我们得出的结论是，与已知的空间接受野的皮层层次相似，人类大脑中存在一个逐渐延长的时间接受窗的层次。
Real-world events unfold at different time scales and, therefore, cognitive and neuronal processes must likewise occur at different time scales. We present a novel procedure that identifies brain regions responsive to sensory information accumulated over different time scales. We measured functional magnetic resonance imaging activity while observers viewed silent films presented forward, backward, or piecewise-scrambled in time. Early visual areas (e. g., primary visual cortex and the motion-sensitive area MT+) exhibited high response reliability regardless of disruptions in temporal structure. In contrast, the reliability of responses in several higher brain areas, including the superior temporal sulcus (STS), precuneus, posterior lateral sulcus (LS), temporal parietal junction (TPJ), and frontal eye field (FEF), was affected by information accumulated over longer time scales. These regions showed highly reproducible responses for repeated forward, but not for backward or piecewise-scrambled presentations. Moreover, these regions exhibited marked differences in temporal characteristics, with LS, TPJ, and FEF responses depending on information accumulated over longer durations (similar to 36 s) than STS and precuneus (similar to 12 s). We conclude that, similar to the known cortical hierarchy of spatial receptive fields, there is a hierarchy of progressively longer temporal receptive windows in the human brain.