Phonetic mismatch negativity predicts social skills acquisition in schizophrenia
Phonetic mismatch negativity predicts social skills acquisition in schizophrenia
复制标题
DOI：
10.1016/j.psychres.2006.02.010
复制
发表时间：
2007-08-30
影响因子：
11.3
通讯作者：
Kasai, Kiyoto
中科院分区：
文献类型：
--
作者：
Kawakubo, Yuki;Kamio, Satoru;Kasai, Kiyoto
精神分裂症患者社会技能获得的神经生物学机制在很大程度上仍然未知。我们调查了认知功能的电生理指标是否可以预测精神分裂症患者与训练相关的社交技能改善程度。对13例精神分裂症患者进行了事件相关电位（MMN）评估，随后参加了为期3个月的社会技能训练。较大的右额叶/颞叶MMN电流密度值引起的acrosphoneme的变化显着相关的个人程度的改善，总的社会技能分数评估的结构化的角色扮演测试。虽然是初步的，这些结果表明，语音MMN可能是精神分裂症患者社会技能获得的指标。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Neurobiological mechanisms for social skills acquisition in schizophrenia remain largely unknown. We investigated whether an electrophysiological index of cognitive function predicts the degree of training-related social skills improvement in schizophrenia. Thirteen patients with schizophrenia underwent assessment of mismatch negativity (MMN) event-related potentials, followed by participation in a 3-month social skills training. Larger right frontal/temporal MMN current density values elicited by acrossphoneme change were significantly associated with individual degrees of improvement in total social skills scores as assessed by a structured role play test. Although preliminary, these results suggest that phonetic MMN could be an index of social skills acquisition in patients with schizophrenia. (c) 2006 Elsevier Ireland Ltd. All rights reserved.