Extracellular matrix bioscaffolds in tissue remodeling and morphogenesis.
Extracellular matrix bioscaffolds in tissue remodeling and morphogenesis.
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DOI：
10.1002/dvdy.24379
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Badylak SF
中科院分区：
文献类型：
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作者：
Swinehart IT;Badylak SF
在正常形态发生过程中，细胞外基质（ECM）影响细胞的运动、增殖、凋亡和分化。组织工程学家试图利用ECM的细胞信号传导潜能，促进受伤或缺失的成人组织的功能性重建（如果不能再生的话），否则这些组织会通过形成瘢痕组织来愈合。源于脱细胞组织的ECM生物支架已被用于在许多临床应用中促进合适部位的功能性组织的形成，包括骨骼肌、纤维软骨、下尿路和食管重建等。这些支架通过释放或暴露生长因子和隐蔽肽、调节免疫反应以及招募祖细胞来发挥作用。在此，我们描述ECM诱导的建设性重塑过程，并研究其与正常组织形态发生的相似之处。
During normal morphogenesis the extracellular matrix (ECM) influences cell motility, proliferation, apoptosis, and differentiation. Tissue engineers have attempted to harness the cell signaling potential of ECM to promote the functional reconstruction, if not regeneration, of injured or missing adult tissues that otherwise heal by the formation of scar tissue. ECM bioscaffolds, derived from decellularized tissues, have been used to promote the formation of site appropriate, functional tissues in many clinical applications including skeletal muscle, fibrocartilage, lower urinary tract, and esophageal reconstruction, among others. These scaffolds function by the release or exposure of growth factors and cryptic peptides, modulation of the immune response, and recruitment of progenitor cells. Herein, we describe this process of ECM induced constructive remodeling and examine similarities to normal tissue morphogenesis.