Synthesis, Structure and in vitro Antitumor Activity of a Multinuclear Diorganotin(IV) Complex [(n‐Bu)4Sn2{2,5‐F2C6H3C(O)NHO}2{2,5‐F2C6H3C(NO)O}]2
Synthesis, Structure and in vitro Antitumor Activity of a Multinuclear Diorganotin(IV) Complex [(n‐Bu)4Sn2{2,5‐F2C6H3C(O)NHO}2{2,5‐F2C6H3C(NO)O}]2
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DOI：
10.1002/cjoc.201090068
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发表时间：
2010-02
影响因子：
5.4
通讯作者：
X. Shang;Xiang-gao Meng;Qingshan Li
中科院分区：
文献类型：
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作者：
X. Shang;Xiang-gao Meng;Qingshan Li
合成了一种新的多核二丁基锡(IV)配合物[(n-Bu)4Sn2{2，5-F2C6H3C(O)NHO}2{2，5-F2C6H3C(NO)O}]21，，并通过熔点测定、元素分析、FT-IR、~1H、~(13)C、~(119)Sn核磁共振谱和X-射线衍射法对其结构进行了表征。该化合物对小鼠肉瘤细胞株S-180的体外抗肿瘤活性高于临床常用的5-氟尿嘧啶(5-FU)。
A new multinuclear dibutyltin(IV) complex [(n-Bu)4Sn2{2,5-F2C6H3C(O)NHO}2{2,5-F2C6H3C(NO)O}]21, was synthesized and structurally characterized by melting point measurement, elemental analysis, FT-IR, 1H, 13C, 119Sn NMR spectroscopies, and X-ray diffraction analysis. The complex exhibited in vitro antitumor activity against a murine sarcoma carcinoma cell line (S-180), which was higher than that of 5-fluorouracil (5-Fu), currently used clinically as an antitumor agent.