Caloric restriction prevents the progression of murine AApoAII amyloidosis
Caloric restriction prevents the progression of murine AApoAII amyloidosis
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热量限制可预防小鼠 AApoAII 淀粉样变性的进展
DOI：
10.1080/13506129.2017.1295948
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
K. Higuchi
中科院分区：
文献类型：
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作者：
J. Sawashita;Lin Li;Yingye Liu;Xin Ding;Mu Yang;Zhe Xu;K. Higuchi
在鼠AApoAII淀粉样变性中，错误折叠的血浆载脂蛋白（Apo）A-II在与衰老相关的过程中沉积为AApoAII淀粉样纤维[1]。营养控制，除了其促进健康的能力，可能是最合理和最基本的治疗;事实上，热量限制（CR）经常被报道为最有效的非遗传治疗，以减缓衰老，延长寿命和健康[2，3]。我们证明CR阻止小鼠AApoAII淀粉样变性的进展，并研究其分子机制。
In murine AApoAII amyloidosis, misfolded plasma apolipoprotein (Apo) A-II is deposited as AApoAII amyloid fibrils during a process associated with aging [1]. Nutritional control, in addition to its health-promoting capabilities, may be the most plausible and fundamental treatment; in fact, caloric restriction (CR) has often been reported as the most effective non-genetic treatment to decelerate aging and extend lifespan and healthspan [2,3]. We demonstrated that CR prevented the progression of AApoAII amyloidosis in mice and investigated the molecular mechanisms.