CSF norepinephrine concentrations in posttraumatic stress disorder
CSF norepinephrine concentrations in posttraumatic stress disorder
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DOI：
10.1176/appi.ajp.158.8.1227
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发表时间：
2001-08-01
影响因子：
17.7
通讯作者：
Kasckow, JW
中科院分区：
文献类型：
--
作者：
Geracioti, TD;Baker, DG;Kasckow, JW
Objective.尽管有证据表明创伤后应激障碍（PTSD）中外周和中枢神经系统（CNS）去甲肾上腺素能活性反应过度，但缺乏对PTSD中CNS去甲肾上腺素的直接测量。本研究的目的是确定连续CSF去甲肾上腺素水平PTSD.Method：CSF样本连续超过6小时的时间内，在11名男性战斗退伍军人慢性PTSD和8名健康男性通过留置蛛网膜下腔导管。因此，作者能够在基线（无应激）条件下测定每小时CSF去甲肾上腺素浓度。采用PTSD量表评定患者PTSD症状的严重程度。脑脊液去甲肾上腺素浓度显着高于PTSD男性比健康男性。此外，脑脊液去甲肾上腺素水平与PTSD症状的严重程度呈显著正相关，血浆去甲肾上腺素水平与PTSD症状的严重程度无显著相关性。这些发现揭示了慢性创伤后应激障碍患者在基线条件下比健康受试者存在更大的中枢神经系统去甲肾上腺素能活性，并将这种病理生理学观察与临床创伤后应激的严重程度直接联系起来综合征
Objective. Despite evidence of hyperresponsive peripheral and central nervous system (CNS) noradrenergic activity in posttraumatic stress disorder (PTSD), direct measures of CNS norepinephrine in PTSD have been lacking. The goal of this study was to determine serial CSF norepinephrine levels in patients with PTSD.Method: CSF samples were obtained serially over a 6-hour period in 11 male combat veterans with chronic PTSD and eight healthy men through an indwelling subarachnoid catheter. Thus the authors were able to determine hourly CSF norepinephrine concentrations under baseline (unstressed) conditions. Severity of the patients' PTSD symptoms was assessed with the Clinician-Administered PTSD Scale.Results. CSF norepinephrine concentrations were significantly higher in the men with PTSD than in the healthy men. Moreover, CSF norepinephrine levels strongly and positively correlated with the severity of PTSD symptoms, Plasma norepinephrine concentrations showed no significant relationship with the severity of PTSD symptoms.Conclusions: These findings reveal the presence of greater CNS noradrenergic activity under baseline conditions in patients with chronic PTSD than in healthy subjects and directly link this pathophysiologic observation with the severity of the clinical posttraumatic stress syndrome.