Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling
Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling
复制标题
DOI：
10.1016/s0092-8674(00)00012-x
复制
发表时间：
2000-07-07
期刊：
影响因子：
64.5
通讯作者：
Lemke, G
中科院分区：
文献类型：
--
作者：
Brown, A;Yates, PA;Lemke, G
地形图是神经系统感觉表征的基本特征。通过视网膜中的神经节细胞与它们在中脑的上级丘中的靶的连接来定义的一个这样的图谱的形成被认为取决于视网膜EphA受体和丘肝配蛋白-α配体的互补梯度之间的相互作用。我们已经通过使用基因靶向来提高小鼠神经节细胞亚群中EphA受体表达来测试了这一假设，从而产生了表达不同EphA受体梯度的两个混合的神经节细胞群体。我们发现，这两个群体形成单独的地图在丘，这可以预测为一个给定的神经节细胞表达相对于其邻居的净EphA受体水平的函数。
Topographic maps are a fundamental feature of sensory representations in nervous systems. The formation of one such map, defined by the connection of ganglion cells in the retina to their targets in the superior colliculus of the midbrain, is thought to depend upon an interaction between complementary gradients of retinal EphA receptors and collicular ephrin-a ligands. We have tested this hypothesis by using gene targeting to elevate EphA receptor expression in a subset of mouse ganglion cells, thereby producing two intermingled ganglion cell populations that express distinct EphA receptor gradients. We find that these two populations form separate maps in the colliculus, which can be predicted as a function of the net EphA receptor level that a given ganglion cell expresses relative to its neighbors.