Local mechanisms regulating selective cargo entry and long-range trafficking in axons
Local mechanisms regulating selective cargo entry and long-range trafficking in axons
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DOI：
10.1016/j.conb.2018.02.007
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发表时间：
2018-08-01
影响因子：
5.7
通讯作者：
Hoogenraad, Casper C.
中科院分区：
文献类型：
--
作者：
Gumy, Laura F.;Hoogenraad, Casper C.
神经元货物的极化长距离运输依赖于功能性和结构性轴突亚室的存在。鉴于神经元货物的异质性，选择性分选和进入发生在近端轴突，其中多个亚细胞特化，如轴突初始段、轴突前隔离区、MAP2轴突前过滤区和Tau扩散屏障提供不同程度的调节。允许通过近端轴突的货物扩散到更远的部分。最近的研究结果表明，沿轴突的不同货物分布取决于细胞骨架的区隔组织和微管相关蛋白对多种运动蛋白的局部调节。在这篇综述中，我们关注控制货物运动的局部机制，并讨论它们如何在轴突货物的整体循环中发挥作用。
The polarized long-distance transport of neuronal cargoes depends on the presence of functional and structural axonal subcompartments. Given the heterogeneity of neuronal cargoes, selective sorting and entry occurs in the proximal axon where multiple subcellular specializations such as the axon initial segment, the pre-axonal exclusion zone, the MAP2 pre-axonal filtering zone and the Tau diffusion barrier provide different levels of regulation. Cargoes allowed to pass through the proximal axon spread into the more distal parts. Recent findings show that diverse cargo distributions along the axon depend on the compartmentalized organization of the cytoskeleton and the local regulation of multiple motor proteins by microtubule associated proteins. In this review, we focus on the local mechanisms that control cargo motility and discuss how they play a role in the overall circulation of axonal cargoes.