Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells
Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells
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DOI：
10.1016/j.mcn.2005.11.010
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发表时间：
2006-03-01
影响因子：
3.5
通讯作者：
Gage, FH
中科院分区：
文献类型：
--
作者：
Ray, J;Gage, FH
成体神经干细胞/前体细胞在所有哺乳动物中枢神经系统的离散区域发生神经发生，但调节内源性神经发生的机制尚不清楚。了解神经发生的进展依赖于了解它们的内在属性和对控制它们行为的环境信号的反应。在解决这些问题之前，有必要了解来自两个通常研究的模型系统-小鼠和大鼠的中枢神经系统来源的干/祖细胞的特性是否存在显著的物种特异性差异。我们发现大鼠和小鼠的干细胞/祖细胞对不同的底物、有丝分裂生长因子和肝素的反应以及分化因素对神经元和神经胶质细胞生成的影响有很大的差异。因此，基于对这些细胞的研究，从一个物种到另一个物种的细胞属性的推断应该谨慎进行。(C)2005 Elsevier Inc.保留所有权利。
Adult neurogenesis from neural stem/progenitor cells occurs in discrete regions of the central nervous system of all mammals, but the mechanisms regulating endogenous neurogenesis are poorly understood. Advances in understanding the neurogenesis depend on knowing their intrinsic properties and responses to environmental signals that control their behavior. Before these issues can be addressed, it is necessary to know whether there are significant species-specific differences in the properties of the stem/progenitor cells derived from CNS of two commonly studied model systems, mouse and rat. We found major differences between rat and mouse stem/progenitor cell proliferation in response to various substrates, mitogenic growth factors and heparin and to the influence of differentiation factors on generation of neurons and glia. Thus, extrapolation of cell properties from one species to another based on studies of these cells should be made with caution. (c) 2005 Elsevier Inc. All rights reserved.