Functional properties of single neurons in the face primary motor cortex of the primate. II. Relations with trained orofacial motor behavior.
Functional properties of single neurons in the face primary motor cortex of the primate. II. Relations with trained orofacial motor behavior.
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灵长类动物面部初级运动皮层单个神经元的功能特性。
DOI：
10.1152/jn.1992.67.3.759
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发表时间：
1992
影响因子：
2.5
通讯作者：
B. Sessle
中科院分区：
文献类型：
--
作者：
G. M. Murray;B. Sessle
1.先前的论文已经详细描述了位于灵长类动物面部运动皮层内的单个神经元的输入和输出特征，（ICMS，小于或等于20微安）在最低阈值下诱发舌运动（“舌-MI”部位）;为了比较的目的，我们还报道了在ICMS引起下颌运动的部位记录的少量神经元的输入和输出特征（“下颌-MI”位点）、面部运动（“面部-MI”位点），或者在少数位点，舌头运动，以及在相同的阈值强度下，下颌运动或面部运动。2.我们的研究结果表明，猴子面部运动皮层内用于产生舌头运动基本成分的部位广泛而多样，并且可以诱发下颌闭合运动的部位相对较少，这与我们最近的观察结果一致，即可逆的，冷却引起的面部运动皮层失活严重损害了猴子的舌头表现，突出任务，但只有相对较小的影响上的性能咬任务。在试图建立一个神经元相关的这些不同的行为关系，本研究记录了任务相关的活动，其特征在于在前一篇文章中的传入输入和ICMS定义的输出功能的单神经元。3.每项任务都要求每只猴子在最短的时间内发展和维持一个固定的力量水平，以获得果汁奖励。在这些任务中的一个或两个，我们的特点是231个单面运动皮层神经元，位于上述ICMS定义的网站的活动。如果神经元在任务期间的放电率与对照试验前阶段（PTP）相比显示出统计学上的显著差异，则可以说它们与特定任务有关。4.在舌MI，有一个显着较高的比例的神经元（63%的156个神经元测试），与舌头伸出任务比咬任务（15%的65）。然而，在下颌-MI的咬任务相关的神经元的比例（63%的19）是显着高于相关的舌头伸出任务的比例（11%的9）;在ICMS定义的下颌关闭网站的咬任务相关的神经元的比例也高于在下颌打开网站。（400字处截断摘要）
1. The previous paper has described in detail the input and output features of single neurons located at sites within primate face motor cortex from which intracortical microstimulation (ICMS, less than or equal to 20 microA) evoked tongue movements at the lowest threshold ("tongue-MI" sites); for comparative purposes, we also reported on the input and output features of a smaller number of neurons recorded at sites from which ICMS could evoke jaw movements ("jaw-MI" sites), facial movements ("face-MI" sites), or, at a few sites, tongue movements and, at the same threshold intensity, either a jaw movement or a facial movement. 2. Our findings of an extensive and diverse representation of sites within face motor cortex of monkeys for the generation of elemental components of tongue movement, and the relatively few sites from which jaw-closing movements could be evoked, were consistent with our recent observations that reversible, cooling-induced inactivation of the face motor cortex severely impaired the performance by monkeys of a tongue-protrusion task but had only relatively minor effects on the performance of a biting task. In an attempt to establish a neuronal correlate for these different behavioral relations, the present study has documented the task-related activities of those single neurons that were characterized in the previous paper in terms of afferent input and ICMS-defined output features. 3. Each task required the development and maintenance by each monkey of a fixed force level for a minimum period of time to obtain a fruit-juice reward. During one or both of these tasks, we characterized the activities of 231 single face motor cortical neurons that were located at the above-mentioned ICMS-defined sites. Neurons were said to be related to a particular task if they showed statistically significant differences in firing rates during the task in comparison with a control pretrial period (PTP). 4. In tongue-MI, there was a significantly higher proportion of neurons (63% of 156 neurons tested) that were related to the tongue-protrusion task than to the biting task (15% of 65). However, in jaw-MI the proportion of neurons that were biting task-related (63% of 19) was significantly higher than the proportion related to the tongue-protrusion task (11% of 9); the proportion of biting task-related neurons at ICMS-defined jaw-closing sites was also higher than that at jaw-opening sites.(ABSTRACT TRUNCATED AT 400 WORDS)