Visual feature conjunction in patients with schizophrenia: an event-related brain potential study
Visual feature conjunction in patients with schizophrenia: an event-related brain potential study
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DOI：
10.1016/s0920-9964(01)00303-6
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发表时间：
2002-09-01
影响因子：
4.5
通讯作者：
Zipursky, RB
中科院分区：
文献类型：
--
作者：
Alain, C;Bernstein, LJ;Zipursky, RB
The neural mechanisms supporting performance during single feature and feature conjunction detection were investigated in patients with schizophrenia and age-matched controls using event-related brain potentials. In different blocks of trials, participants responded to visual targets defined by one of two colors, one of two orientations, or both color and orientation. All participants were faster and more accurate in detecting targets defined by a single feature than for targets defined by a conjunction of features. Relative to controls, patients made more errors and were slower in detecting targets defined by a combination of features. Patients also generated a smaller N2 wave to single and conjunctive targets, and showed greater P3b reduction over the right hemisphere for conjunctive targets than for targets defined by color only. In addition, target stimuli generated an increased negativity at the occipital sites that varied in scalp distribution with the attended features in controls but not in patients. Both behavioral and electrophysiological data provide converging evidence for deficits in integrating visual features in schizophrenia and suggest that processing features of visual objects in schizophrenia are partly supported by distinct functional networks. (C) 2002 Elsevier Science B.V. All rights reserved.
