Short Sleep Duration Increases Metabolic Impact in Healthy Adults: A Population-Based Cohort Study
Short Sleep Duration Increases Metabolic Impact in Healthy Adults: A Population-Based Cohort Study
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DOI：
10.1093/sleep/zsx130
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发表时间：
2017-10-01
期刊：
影响因子：
5.6
通讯作者：
Lao, Xiang Qian
中科院分区：
文献类型：
--
作者：
Deng, Han-Bing;Tam, Tony;Lao, Xiang Qian
目的：睡眠不足对代谢的影响尚未在实验室外的健康个体中确定。本研究旨在探讨睡眠时间对健康成人队列中代谢综合征5个组成部分的影响。方法：从1996年至2014年，共招募了MJ健康数据库中162 121名年龄在20-80岁（男性47.4%）的成年人，他们不肥胖，也没有重大疾病。睡眠持续时间和失眠症状通过自填问卷进行评估。通过随访医学检查确定了5种代谢综合征组分的事件病例。计算三种睡眠时间类别“< 6小时/天（短）”、“6-8小时/天（常规）”和“> 8小时/天（长）”的考克斯比例风险比（HR），并调整潜在的混杂因素。分析按失眠症状分层，以评估失眠症状是否改变了睡眠时间与代谢综合征之间的关联。与正常睡眠时间相比，短睡眠时间（p < .001）增加了12%的中心性肥胖的风险（校正HR 1.12 [1.07-1.17]），空腹血糖升高6%（调整HR 1.06 [1.03-1.09]），高血压降低8%（调整HR 1.08 [1.04-1.13]），低高密度脂蛋白胆固醇降低7%（校正HR 1.07 [1.03-1.11]），高甘油三酯血症降低9%（校正HR 1.09 [1.05-1.13]），代谢综合征降低9%（校正HR 1.09 [1.05-1.13]）。长时间睡眠可降低高甘油三酯血症（校正HR 0.89 [0.84-0.94]）和代谢综合征（校正HR 0.93 [0.88-0.99]）的风险。失眠症状并没有改变睡眠持续时间的影响。结论：睡眠持续时间可能是代谢健康的一个重要决定因素。
Objectives: The metabolic impact of inadequate sleep has not been determined in healthy individuals outside laboratories. This study aims to investigate the impact of sleep duration on five metabolic syndrome components in a healthy adult cohort.Methods: A total of 162 121 adults aged 20-80 years (men 47.4%) of the MJ Health Database, who were not obese and free from major diseases, were recruited and followed up from 1996 to 2014. Sleep duration and insomnia symptoms were assessed by a self-administered questionnaire. Incident cases of five metabolic syndrome components were identified by follow-up medical examinations. Cox proportional hazard ratios (HRs) were calculated for three sleep duration categories "< 6 hours/day (short)," "6-8 hours/day (regular)," and "> 8 hours/day (long)" with adjustment for potential confounding factors. Analyses were stratified by insomnia symptoms to assess whether insomnia symptoms modified the association between sleep duration and metabolic syndrome.Results: Compared to regular sleep duration, short sleep significantly (p < .001) increased the risk for central obesity by 12% (adjusted HR 1.12 [1.07-1.17]), for elevated fasting glucose by 6% (adjusted HR 1.06 [1.03-1.09]), for high blood pressure by 8% (adjusted HR 1.08 [1.04-1.13]), for low high-density lipoprotein-cholesterol by 7% (adjusted HR 1.07 [1.03-1.11]), for hypertriglyceridemia by 9% (adjusted HR 1.09 [1.05-1.13]), and for metabolic syndrome by 9% (adjusted HR 1.09 [1.05-1.13]). Long sleep decreased the risk of hypertriglyceridemia (adjusted HR 0.89 [0.84-0.94]) and metabolic syndrome (adjusted HR 0.93 [0.88-0.99]). Insomnia symptoms did not modify the effects of sleep duration.Conclusions: Sleep duration may be a significant determinant of metabolic health.