Resolution of Hypertension and Proteinuria After Preeclampsia
Resolution of Hypertension and Proteinuria After Preeclampsia
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DOI：
10.1097/aog.0b013e3181c14e3e
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发表时间：
2009-12-01
影响因子：
7.2
通讯作者：
Fisser, Willy
中科院分区：
文献类型：
--
作者：
Berks, Durk;Steegers, Eric A. P.;Fisser, Willy
目的：估计子痫前期后高血压和蛋白尿消退所需的时间，并估计这一时间与子痫前期期间血压和蛋白尿水平以及子痫前期发展后延长妊娠时间的相关性。方法：这是一项历史性的前瞻性队列研究，研究对象为1990年至1992年在鹿特丹的伊拉斯谟MC医学中心住院的205名先兆子痫妇女，荷兰.在分娩后1.5、3、6、12、18和24个月收集数据。高血压定义为血压140/90 mm Hg或更高或使用抗高血压药物。蛋白尿定义为0.3 g/d或更多。高血压和蛋白尿的解决进行了分析与特恩布尔扩展的Kaplan-Meier程序。相关性计算与加速故障时间model.Results：在产后3个月，39%的妇女仍然有高血压，这在产后2年下降到18%。解决时间增加60%（P
OBJECTIVE: To estimate the time required for hypertension and proteinuria to resolve after preeclampsia, and to estimate how this time to resolution correlates with the levels of blood pressure and proteinuria during preeclampsia and prolonging pregnancy after the development of preeclampsia.METHODS: This is a historic prospective cohort study of 205 preeclamptic women who were admitted between 1990 and 1992 at the Erasmus MC Medical Centre, Rotterdam, The Netherlands. Data were collected at 1.5, 3, 6, 12, 18, and 24 months after delivery. Hypertension was defined as a blood pressure 140/90 mm Hg or higher or use of anti hypertensive drugs. Proteinuria was defined as 0.3 g/d or more. Resolution of hypertension and proteinuria were analyzed with the Turnbull extension to the Kaplan-Meier procedure. Correlations were calculated with an accelerated failure time model.RESULTS: At 3 months postpartum, 39% of women still had hypertension, which decreased to 18% at 2 years postpartum. Resolution time increased by 60% (P