Brain redox imaging.
Brain redox imaging.
复制标题
DOI：
10.1007/978-1-61737-992-5_20
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Krishna MC
中科院分区：
文献类型：
--
作者：
Matsumoto K;Hyodo F;Anzai K;Utsumi H;Mitchell JB;Krishna MC
氮氧基造影剂(氮氧基自由基，也称为氮氧化物)是顺磁性物种，它可以与活性氧物种(ROS)反应，失去顺磁性而成为抗磁性物种。可以使用电子顺磁共振成像(EPRI)、Overhauser MRI(OMRI)或MRI来检测顺磁性氮氧自由基形式。顺磁性氧化还原敏感型造影剂诱导的体内图像强度的时间进程可以提供组织的氧化还原信息，即所谓的氧化还原成像技术。氧化还原成像技术采用血脑屏障透过性氮氧化物造影剂，可用于分析脑内的病理生理功能。简述了氧化还原成像技术的基本原理，介绍了氧化还原成像技术在脑成像中的应用。
Nitroxyl contrast agents (nitroxyl radicals, also known as nitroxide) are paramagnetic species, which can react with reactive oxygen species (ROS) to lose paramagnetism to be diamagnetic species. The paramagnetic nitroxyl radical forms can be detected by using electron paramagnetic resonance imaging (EPRI), Overhauser MRI (OMRI), or MRI. The time course of in vivo image intensity induced by paramagnetic redox-sensitive contrast agent can give tissue redox information, which is the so-called redox imaging technique. The redox imaging technique employing a blood–brain barrier permeable nitroxyl contrast agent can be applied to analyze the pathophysiological functions in the brain. A brief theory of redox imaging techniques is described, and applications of redox imaging techniques to brain are introduced.