Induced primaquine resistance in vivax malaria
Induced primaquine resistance in vivax malaria
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DOI：
10.1016/0035-9203(61)90103-1
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发表时间：
1961-01-01
期刊：
影响因子：
--
通讯作者：
HOCHWALD, R. S.
中科院分区：
文献类型：
--
作者：
ARNOLD, J.;ALVING, A. S.;HOCHWALD, R. S.
在实验室条件下，36个连续亚接种的单一菌株间日疟原虫疟疾，在此期间采用次优的治疗引起了显着增加滋养体耐药性的药物伯氨喹。人类志愿者耐受的伯氨喹的最大剂量对最后几次接种产生的寄生虫血症不再有任何影响。显然，完全存活的配子母细胞可以转移到蚊子身上，并发育成孢子，尽管这种孢子未能感染人类。伯氨喹引起疟疾有机体的耐药间日疟原虫株的发展的能力表明，除了伯氨喹治疗外，还需要使用良好的血液抗寄生虫剂。|| 摘要：A C。沃尔顿
Under laboratory conditions, 36 sequential subinoculations of a single strain of Plasmodium vivax malaria during which suboptimal treatments were employed gave rise to a significant increase in trophozoite resistance to the drug primaquine. The maximum dose of primaquine tolerated by human volunteers no longer had any effect on the parasitemia developed by the last few subinoculations. Apparently fully-viable gametocytes could be transferred to mosquitoes and develop into sporo-zoites, although such sporozoites failed to infect man. The capacity of primaquine to cause the development of a resistant P. vivax strain of malarial organisms indicates the desirability of using a good blood schizontocide in addition to primaquine therapy. || ABSTRACT AUTHORS: A C. Walton