Increased expression of discoidin domain receptor 2 (DDR2): a novel independent prognostic marker of worse outcome in breast cancer patients
Increased expression of discoidin domain receptor 2 (DDR2): a novel independent prognostic marker of worse outcome in breast cancer patients
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盘状蛋白结构域受体 2 (DDR2) 表达增加：乳腺癌患者预后较差的新型独立预后标志物
DOI：
10.1007/s12032-012-0397-3
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发表时间：
2013-03-01
期刊：
影响因子：
3.4
通讯作者：
Yao, Libo
中科院分区：
文献类型：
--
作者：
Ren, Tingting;Zhang, Jian;Yao, Libo
盘状结构域受体DDR 1和DDR2与许多人类癌症有关。我们试图确定人类乳腺癌中DDRs的表达水平和分布，并研究预后因素以确定DDRs水平是否可以预测生存。分析来自122名乳腺癌患者的肿瘤样品的DDR的相对表达。另外24个匹配的肿瘤和正常组织进行了DDR 1和DDR2的差异表达测试。与正常乳腺组织相比，发现肿瘤中DDR2显著增加6倍（P= 0.0005），DDR 1降低（P= 0.0001）。DDR 1表达与患者生存率无相关性，而DDR2表达与无病生存率（HR = 0.55，95%CI = 0.24- 0.78，P = 0.026）和总生存率（HR = 0.46，95%CI = 0.35- 0.84，P = 0.019）显著相关。多变量分析显示，DDR2是独立于肿瘤分期、组织学和患者年龄的预后的独立有利预测因子。目前的研究提供了第一个证据，表明原发性人类乳腺癌中DDR2 mRNA表达的增加可能是复发和结果的强大，独立的预测因子。
The discoidin domain receptors, DDR1 and DDR2, have been linked with numerous human cancers. We sought to determine expression level and distribution of DDRs in human breast cancer, and investigate prognostic determinates to determine whether levels of DDRs could predict survival. Tumor samples from 122 breast cancer patients were analyzed for relative expression of DDRs. An additional 24 matched tumor and normal tissues were tested for differential expression of DDR1 and DDR2. DDR2 was found to be significantly increased by 6-fold (P= 0.0005) and DDR1 decreased (P= 0.0001) in tumor vs. normal breast tissue. DDR1 expression was not predictive for patient survival; however, DDR2 expression was significantly associated with disease-free (HR = 0.55, 95 % CI = 0.24–0.78,P= 0.026) and overall survival (HR = 0.46, 95 % CI = 0.35–0.84,P= 0.019). Multivariate analysis revealed DDR2 is an independent favorable predictor for prognosis independent of tumor stage, histology, and patient age. The present research provided the first evidence that increased DDR2 mRNA expression in primary human breast cancer might be a powerful, independent predictor of recurrence and outcome.