T helper cell related interleukins and the anglographic morphology in unstable angina
T helper cell related interleukins and the anglographic morphology in unstable angina
复制标题
DOI：
10.1016/j.cyto.2005.02.008
复制
发表时间：
2005-06-07
期刊：
影响因子：
3.8
通讯作者：
Guo, HP
中科院分区：
文献类型：
--
作者：
Baidya, SG;Zeng, QT;Guo, HP
血管造影可见的复杂病变，与破裂的斑块和腔内血栓相关，在不稳定型心绞痛（UA）中更常见。本研究的目的是探讨复杂性病变与T辅助细胞相关白细胞介素（IL）的关系。采用酶联免疫吸附试验（ELISA）检测50例UA患者血清中IL-10、IL-12、IL-18的浓度，采用乳胶增强免疫比浊法检测hsCRP的浓度。其中31例患者有复杂病变，19例患者在冠状动脉造影期间可见简单病变。我们进一步将他们与30名没有冠状动脉疾病证据的对照组进行了比较。复杂病变组IL-12水平高于单纯病变组，IL-10水平低于单纯病变组，但差异无统计学意义。与简单病变患者相比，复杂病变患者的IL-18浓度显着更高。此外，IL-18被发现是UA患者中复杂病变形态的独立预测因子。这些结果表明，破裂斑块和管腔内血栓，血管造影可见的复杂病变与T辅助细胞I相关的白细胞介素，主要是IL-18的浓度增加有关，IL-18是UA风险分层的可能生物标志物。(c)2005爱思唯尔有限公司保留所有权利。
Angiographically visible complex lesions, associated with disrupted plaques and intraluminal thrombus, are more common in unstable angina (UA). The aim of our study was to evaluate the relationship between the complex lesions And the T helper cells related Interleukins (IL). We analyzed the concentrations of IL-10, IL-12, IL-18 using ELISA and that of hsCRP using Latex particle enhanced Immunoturbidimetry in 50 patients of UA. Thirty-one of these patients had complex lesions and 19 had simple lesions as visible during coronary angiography. We further compared them with 30 control subjects having no evidence of coronary artery diseases. The levels of IL-12 in patients having complex lesions tended to be higher than in those having simple lesions and levels of IL-10 tended to be lower in the former than the latter, but the differences were not statistically significant. The patients with complex lesions showed significantly higher concentrations of IL-18 as compared to those having simple lesions. Furthermore, IL-18 was found to be independent predictor for the complex lesion morphology in UA patients. These findings suggest that disrupted plaques and intraluminal thrombus, angiographically visible as complex lesions are associated with increased concentrations of T helper I cell related interleukins, mainly IL-18, and IL-18 being a possible bio-marker for risk stratification in UA. (c) 2005 Elsevier Ltd. All rights reserved.