Neural substrates of spoken language rehabilitation in an aphasic patient:: An fMRI study
Neural substrates of spoken language rehabilitation in an aphasic patient:: An fMRI study
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DOI：
10.1006/nimg.2002.1238
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发表时间：
2002-09-01
期刊：
影响因子：
5.7
通讯作者：
Cardebat, D
中科院分区：
文献类型：
--
作者：
Léger, A;Démonet, JF;Cardebat, D
对失语症患者的语言治疗的神经对应物知之甚少。在RC（左侧缺血性病变后出现长期言语输出缺陷的患者）接受特定的强化言语输出治疗前后进行fMRI实验。公开图片命名和图片/词押韵被用作激活任务的RC和6名控制被试。命名任务涉及对输出词汇缺陷的修复，而押韵任务涉及保留的加工水平，并用于控制重复效应。语言治疗计划改善了命名性能。通过与治疗前观察到的模式相比，治疗后的命名任务诱导的激活模式接近于对照组中观察到的激活模式，涉及病变周围的左侧语言区。言语治疗效应与Broca区和左侧缘上回的激活有关，这可能反映了治疗诱导的命名语音补偿策略。(C)2002年爱思唯尔科学（美国）。
Little is known about the neural counterparts of speech therapy in aphasic patients. An fMRI experiment was performed before and after a specific and intensive speech output therapy in RC, a patient with long-lasting speech output deficit following a left-sided ischemic lesion. Overt picture naming and picture/word rhyming were used as activation tasks in RC and 6 control subjects. The naming task concerned the output lexicon deficit to be rehabilitated while rhyming referred to preserved levels of processing and was used to control for repetition effect. The speech therapy program improved naming performance. By comparison to the pattern observed before therapy, the naming task after therapy induced a pattern of activation close to that observed in control subjects, involving left-sided language areas surrounding the lesion. Speech therapy effect was associated with activations in Broca's area and the left supra-marginal gyrus, which might reflect a therapy-induced phonological compensatory strategy for naming. (C) 2002 Elsevier Science (USA).