A functional role for dopamine transmission in the amygdala during condtioned fear
A functional role for dopamine transmission in the amygdala during condtioned fear
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DOI：
10.1111/j.1749-6632.1999.tb09312.x
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Karp, BS
中科院分区：
文献类型：
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作者：
Guarraci, FA;Frohardt, RJ;Karp, BS
最近的研究表明，中脑多巴胺能系统被条件性恐惧刺激激活。4，9研究还有力地表明，杏仁核是条件性恐惧必不可少的神经回路的关键组成部分，因为对杏仁核的各种操纵会破坏条件性恐惧的获得和表达。[3，6，8]虽然杏仁核被认为是对恐惧刺激做出反应时释放多巴胺的部位，但令人惊讶的是，几乎没有人致力于研究杏仁中核多巴胺系统对恐惧条件反射的具体贡献。本研究旨在探讨杏仁核内注入多巴胺能激动剂和拮抗剂对大鼠巴甫洛夫恐惧的获得和表达的影响，条件性的声音和背景刺激。
Recent research suggests that the mesencephalic dopaminergic system is activated by conditioned fear-arousing stimuli. 4, 9 Research also strongly suggests that the amygdala is a critical component of the neural circuitry essential for conditioned fear, inasmuch as various manipulations of the amygdala disrupt both the acquisition and expression of conditioned fear. 3, 6, 8 Although, the amygdala has been identified as a site of dopamine release in response to fear-arousing stimuli, 2, 5 surprisingly little effort has been devoted to investigating the specific contribution of the mesoamygdaloid dopamine system to fear conditioning. The present study was designed to investigate the effects of intra-amygdaloid infusions of a dopaminergic agonist and antagonist on the acquisition and expression of pavlovian fear, conditioned to acoustic and contextual stimuli in the rat.