Copper Handling in the Salmonella Cell Envelope and Its Impact on Virulence.

Copper Handling in the Salmonella Cell Envelope and Its Impact on Virulence.
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DOI:
10.1016/j.tim.2021.01.004
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发表时间:
2021-05
影响因子:
15.9
通讯作者:
Soncini, Fernando C.
Soncini, Fernando C.
中科院分区:
生物学1区
文献类型:
--
作者:
Checa, Susana K.;Giri, German F.;Espariz, Martin;Arguello, Jose M.;Soncini, Fernando C.

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铜(Cu)既是必需元素,又是有毒元素,在宿主-病原体界面上发挥着关键作用。致病性沙门氏菌的细胞内菌株已经获得了周质铜分子伴侣,CueP和巯基氧化还原酶复合物Scs,同时失去了祖先的铜解毒Cus系统。这些物种特异性因子的协同调节将铜与氧化还原应激联系起来,并允许沙门氏菌在感染期间抵消铜毒性。
Copper (Cu) plays a key role at the host-pathogen interface as both an essential element and a toxic element. Intracellular strains of pathogenic Salmonella have acquired the periplasmic Cu chaperone, CueP, and the thiol oxidoreductases complex Scs, while losing the ancestral Cu-detoxification Cus system. Coregulation of these species-specific factors link Cu with redox stress and allows Salmonella to counteract Cu toxicity during infection.
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