Molecular design for novel sensing materials with self-screening interference effect (SSIE): Reversible recognizing Cu2 in aqueous and biologic samples
Molecular design for novel sensing materials with self-screening interference effect (SSIE): Reversible recognizing Cu2 in aqueous and biologic samples
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具有自屏蔽干扰效应（SSIE）的新型传感材料的分子设计：可逆识别水样和生物样品中的 Cu2
DOI：
10.1016/j.snb.2019.01.142
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Xu Hongyao
中科院分区：
文献类型：
--
作者：
Zhao Gang;Song Fangfang;Wei Gang;Wu Rongliang;Yan Zhengquan;Zhang Fayin;Guang Shanyi;Xu Hongyao
本文提出了以联吡啶为自屏蔽干扰基团，罗丹明为母发色团，三聚氯氰为连接桥，通过简单的热力学控制反应，利用自屏蔽干扰效应（SSIE）对痕量Cu ~（2+）进行传感。通过对其紫外-可见光谱和荧光光谱特性的优化，发现该传感材料（RACD）可以选择性地可逆地与Cu ~（2+）反应，并具有明显的比色或荧光光谱，颜色从无色变为粉红色或橙红色。在优化的条件下，RACD可对水中痕量Cu ~（2+）进行多模式检测，检出限可达11.0 nmol/L。RACD具有毒性低的特点，可用于活细胞和生物组织中Cu ~（2+）的定量检测和毒性评价。还制备了RACD功能化的纸条，以更方便地可见地识别Cu 2+。RACD对Cu ~（2+）的选择性作用机理是Cu ~（2+）与O或N原子之间形成稳定的五元或五元稠环。
In the work, self-screening interference effect (SSIE) was proposed for sensing trace Cu2+by simply thermodynamic control reactions, using dipyridine as self-screening interference group, rhodamine as mother chromophore and cyanuric chloride as connecting bridge. After its UV–vis and fluorescent spectral properties were optimized in detail, it was noted to find that the present sensing material (RACD) could selectively and reversibly react Cu2+with obvious colorimetric or fluorescent spectral and color changes from colorless to pink or orange-red. Some other concomitant ions, even trivalent Fe3+or Al3+, had no interferences on it. Under the optimized conditions, RACD could multiple-mode sense trace Cu2+in aqueous with a detection limit as low as 11.0 nmol/L. Especially with low toxicity, RACD was successfully applied for quantitatively monitoring Cu2+and evaluating its toxicity in living cells and bio-tissues. RACD-functionalized paper-strips were also prepared to visibly recognize Cu2+more conveniently. The selective action mechanism for RACD to Cu2+was to form some stable 5-membered and 5-membered condensed rings between Cu2+and O or N atoms.