SEVERE APLASTIC-ANEMIA ASSOCIATED WITH CHRONIC MUCOCUTANEOUS CANDIDIASIS - IMMUNOLOGICAL AND HEMATOLOGIC RECONSTITUTION AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION
SEVERE APLASTIC-ANEMIA ASSOCIATED WITH CHRONIC MUCOCUTANEOUS CANDIDIASIS - IMMUNOLOGICAL AND HEMATOLOGIC RECONSTITUTION AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION
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DOI：
10.1097/00007890-198605000-00006
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发表时间：
1986-05-01
期刊：
影响因子：
6.2
通讯作者：
STORB, R
中科院分区：
文献类型：
--
作者：
DEEG, HJ;LUM, LG;STORB, R
慢性皮肤粘膜念珠菌病（CMC）通常与T淋巴细胞不能增殖和产生淋巴因子应答念珠菌抗原有关。一名7岁的CMC女孩发生了严重的再生障碍性贫血，在用环磷酰胺（200 mg/kg）预处理后，接受了其HLA相同妹妹的骨髓移植。植入迅速且完全。患者移植后存活3年以上，供者造血和免疫功能正常。CMC的表现已完全消退，她已超过2年未接受抗真菌治疗。
Chronic mucocutaneous candidiasis (CMC) is typically associated with the inability of T lymphocytes to proliferate and produce lymphokines in response to Candida antigen. A 7-year-old girl with CMC developed severe aplastic anemia and, after conditioning with cyclophosphamide, 200 mg/kg, underwent bone marrow transplantation from her HLA-identical sister. Engraftment was prompt and complete. The patient is surviving more than 3 years after transplantation with normal donor-derived hemopoiesis and immune function. Manifestations of CMC have resolved completely and she has not received antifungal therapy for more than 2 years.