SU‐GG‐I‐159: In‐Vivo Iron Measurement through Nuclear Resonance Fluorescence
SU‐GG‐I‐159: In‐Vivo Iron Measurement through Nuclear Resonance Fluorescence
复制标题
SU-GG-I-159：通过核磁共振荧光进行体内铁测量
DOI：
10.1118/1.3468195
复制
发表时间：
2010
期刊：
影响因子：
3.8
通讯作者：
C. Howell
中科院分区：
文献类型：
--
作者：
A. Kapadia;G. Agasthya;L. Cumberbatch;C. Howell
体内铁的定量测量一直是一些与人体铁紊乱有关的研究的焦点。SQUID和MRI等技术已被用于检测血色素沉着症和地中海贫血患者的肝铁储量。在这里，我们提出了一种伽马激发光谱方法，通过核共振荧光检测水样品中的铁。用高能调谐伽玛射线束激发悬浮在水中的铁样品的特征伽玛辐射。伽玛光束是由杜克大学的自由电子激光源产生的，并调谐到6.93 MeV，与天然铁（56 - Fe）的6926 keV能态共振。将光束对准并聚焦到浸入水中的天然铁样品上，该样品的铁浓度为180 mg/g。利用浸没在水中的铜模，从光谱采集装置中获得背景噪声的估计。使用高纯度锗（HPGe）探测器生成每个样品的发射伽马光谱，并使用飞行时间技术对背景进行校正。结果表明，样品中的56 - Fe在6926 keV处有一条强伽玛线。该实验证明了通过核共振伽马激发光谱选择性刺激和量化铁中特定能级的能力。通过层析成像，该技术可以扩展到以非侵入性和体内的方式获得肝脏或身体其他器官中铁储量的三维定量地图。
In‐vivo quantitative measurement of iron has been the focus of several studies related to iron disorders in the human body. Techniques such as SQUID and MRI have been used to detect liveriron stores in patients afflicted with hemochromatosis and thalassemia. Here we present a gamma‐stimulated spectroscopy method to detect iron in an aqueous sample through nuclear resonancefluorescence. A high‐energy tuned gamma‐ray beam was used to excite characteristic gamma emission from an iron sample suspended in water. The gamma‐beam was generated using the free‐electron‐laser source at Duke University and tuned to 6.93 MeV to resonate with the 6926 keV energy state in natural iron (56‐Fe). The beam was collimated and focused onto a sample of natural iron immersed in water corresponding to an iron concentration of 180 mg/g. An identical phantom of copper immersed in water was used to obtain an estimate of the background noise from the spectroscopic acquisition setup. Emitted gamma spectra were generated for each sample using a high‐purity germanium (HPGe) detector and background corrected using time‐of‐flight techniques. The resulting spectrum showed a strong gamma line at 6926 keV originating from 56‐Fe in the sample. This experiment demonstrates the ability to selectively stimulate and quantify a specific energy level in iron through nuclear resonance gamma‐stimulated spectroscopy. Through tomographic imaging the technique can be expanded to obtain three‐dimensional quantitative maps of iron stores in the liver or other organs in the body in a manner that is both non‐invasive and in‐vivo.