Diffusion Tensor Imaging Analysis of Subcortical Gray Matter in Patients with Alcohol Dependence
Diffusion Tensor Imaging Analysis of Subcortical Gray Matter in Patients with Alcohol Dependence
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DOI：
10.1007/s00723-020-01272-4
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发表时间：
2020-10-19
影响因子：
1
通讯作者：
Baek, Hyeon-Man
中科院分区：
文献类型：
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作者：
Kim, Yong-Tae;Shim, Jae-Hyuk;Baek, Hyeon-Man
迄今为止，许多研究已经调查了酒精依赖患者的脑白色物质异常使用扩散张量成像（DTI）。弥散张量成像主要用于评价白色物质的完整性，现在越来越多地用于研究灰质（GM），特别是皮质下GM的显微结构变化。我们预测，结构改变可能不仅限于白色物质，但也发现在皮质下GM酒精依赖患者（ADP）。在ADP中研究了磁共振扩散张量成像（DTI）评估的脑微结构与脑体积之间的可能关系。扩散和体积分析进行了21酒精依赖的男性没有神经或躯体并发症，并在21名健康男性。原始体积和DTI参数（即，各向异性分数和扩散率值）的六个皮质下灰质结构（杏仁核、海马体、尾状核、苍白球、壳核、丘脑）。组间（对照组与患者）比较标准化体积，DTI参数，以及组内结构变化和临床变量之间的相关性分析进行。我们的研究结果表明，DTI测量似乎比体积测量更敏感，但这两种方法的结合仍然可以用于检测病理变化。主要表现为左侧海马、双侧壳核和丘脑的宏观结构改变。ADP组大鼠尾状核、海马、壳核体积明显缩小，超微结构发生改变。这些发现可以拓宽我们对ADP的神经解剖学变化的理解。
To date, numerous studies have investigated the brain white matter abnormality in patients with alcohol dependence using diffusion tensor imaging (DTI). DTI has been primarily utilized to evaluate white matter integrity, it is now increasingly used to investigate microstructural changes of gray matter (GM), particularly the subcortical GM. We predicted that structural alterations may not only be restricted to the white matter but also found in subcortical GM in alcohol dependent patients (ADP). Possible relationships between brain microstructure assessed by magnetic resonance diffusion tensor imaging (DTI) and brain volumes were investigated in ADP. Diffusion and volumetric analyses were performed in 21 alcohol dependent men without neurological or somatic complications and in 21 healthy men. Raw volume and DTI parameters (i.e., fractional anisotropy, and diffusivity values) of six subcortical gray matter structures (amygdala, hippocampus, caudate, pallidum, putamen, thalamus) were measured in both hemispheres. Between-group (controls versus patients) comparisons of normalized volume, DTI parameters, as well as within-group correlation analyses between structural changes and clinical variables were carried out. Our results show that DTI measurements appear more sensitive than volume measurements, but the combination of the two methods can still be useful for detecting pathological changes. Major findings are change of macrostructures in left hippocampus and bilateral putamen and thalamus. ADP group exhibited significant volume reductions and change of microstructures in caudate and hippocampus, putamen. These findings can broaden our understanding of the neuroanatomical changes underlying ADP.