Hybrid integrated biological-solid-state system powered with adenosine triphosphate.
Hybrid integrated biological-solid-state system powered with adenosine triphosphate.
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DOI：
10.1038/ncomms10070
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发表时间：
2015-12-07
影响因子：
16.6
通讯作者：
Shepard KL
中科院分区：
文献类型：
--
作者：
Roseman JM;Lin J;Ramakrishnan S;Rosenstein JK;Shepard KL
结合生物和固态的能力来创造混合工程系统有着巨大的潜力。虽然最近有人努力利用植物和动物生命系统中自然发生的电位来为互补金属氧化物半导体集成电路供电，但在这里，我们报告了第一次成功地在体外工程环境中分离出电致离子泵的能量来为这样的人工系统供电。集成电路由三磷酸腺苷通过Na+/K+三磷酸腺苷酶在体外脂质双层膜中的作用提供动力。离子泵（在超过2 × 106 mm−2的膜中有活性）能够维持32.6 pA mm−2的短路电流和78 mV的开路电压，从单个双分子层提供1.27 pW mm−2的最大功率转移。两个串联堆叠的双层层提供的电压足以运行集成电路，化学能转换为电能的效率为14.9%。结合生物和固态的能力来创造混合工程系统有着巨大的潜力。在这里，作者开发了一种技术，将atp酶结合并激活体外膜，以产生可收集能量的电流，为集成电路供电。
There is enormous potential in combining the capabilities of the biological and the solid state to create hybrid engineered systems. While there have been recent efforts to harness power from naturally occurring potentials in living systems in plants and animals to power complementary metal-oxide-semiconductor integrated circuits, here we report the first successful effort to isolate the energetics of an electrogenic ion pump in an engineered in vitro environment to power such an artificial system. An integrated circuit is powered by adenosine triphosphate through the action of Na+/K+ adenosine triphosphatases in an integrated in vitro lipid bilayer membrane. The ion pumps (active in the membrane at numbers exceeding 2 × 106 mm−2) are able to sustain a short-circuit current of 32.6 pA mm−2 and an open-circuit voltage of 78 mV, providing for a maximum power transfer of 1.27 pW mm−2 from a single bilayer. Two series-stacked bilayers provide a voltage sufficient to operate an integrated circuit with a conversion efficiency of chemical to electrical energy of 14.9%. There is enormous potential in combining the capabilities of the biological and the solid-state to create hybrid engineered systems. Here, the authors develop a technique to incorporate and activate ATPases in in vitro membranes to produce energy-harvestable currents to power an integrated circuit.