The developing heart: from The Wizard of Oz to congenital heart disease
The developing heart: from The Wizard of Oz to congenital heart disease
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DOI：
10.1242/dev.194233
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发表时间：
2020-11-01
期刊：
影响因子：
4.6
通讯作者：
Bruneau, Benoit G.
中科院分区：
文献类型：
--
作者：
Bruneau, Benoit G.
心脏是一个重要的器官，具有迷人的发育生物学。它也是在人类疾病中最常受影响的器官之一，无论是在发育期间还是在出生后。在过去的几十年里，对心脏发育的深入了解导致了基因调控的基本新概念，也导致了对先天性心脏缺陷的遗传和机械见解。近年来，从研究心脏发育中吸取的经验教训已被应用于询问患病心脏的再生，这说明了理解导致器官发育的机制基础的重要性。
The heart is an essential organ with a fascinating developmental biology. It is also one of the organs that is most often affected in human disease, either during development or in postnatal life. Over the last few decades, insights into the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased heart, exemplifying the importance of understanding the mechanistic underpinnings that lead to the development of an organ.