PROTEASE NEXIN-II (AMYLOID BETA-PROTEIN PRECURSOR) - A PLATELET ALPHA-GRANULE PROTEIN
PROTEASE NEXIN-II (AMYLOID BETA-PROTEIN PRECURSOR) - A PLATELET ALPHA-GRANULE PROTEIN
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DOI：
10.1126/science.2110384
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发表时间：
1990-05-11
期刊：
影响因子：
56.9
通讯作者：
CUNNINGHAM, DD
中科院分区：
文献类型：
--
作者：
VANNOSTRAND, WE;SCHMAIER, AH;CUNNINGHAM, DD
蛋白酶连接蛋白-II（PN-II）[淀粉样β蛋白前体（APP）]和淀粉样β蛋白是阿尔茨海默病和唐氏综合征患者神经炎斑块和脑血管沉积物的主要成分。大脑和循环都被认为是这些分子的来源，尽管它们在血液中还没有被检测到。人血小板中含有较多的PN-II/APP，它定位于血小板α颗粒中，在血小板活化时分泌。由于PN-II/APP是一种有效的蛋白酶抑制剂，并具有生长因子活性，这些结果暗示PN-II/APP在伤口修复。在某些疾病状态下，血小板释放和PN-II/APP及其衍生片段的加工和清除的改变可能导致这些蛋白质的病理性积聚。
Protease nexin-II (PN-II) [amyloid β-protein precursor (APP)] and the amyloid β-protein are major constituents of neuritic plaques and cerebrovascular deposits in individuals with Alzheimer's disease and Down syndrome. Both the brain and the circulation have been implicated as sources of these molecules, although they have not been detected in blood. Human platelets have now been found to contain relatively large amounts of PN-II/APP. Platelet PN-II/APP was localized in platelet α-granules and was secreted upon platelet activation. Because PN-II/APP is a potent protease inhibitor and possesses growth factor activity, these results implicate PN-II/APP in wound repair. In certain disease states, alterations in platelet release and processing and clearance of PN-II/APP and its derived fragments could lead to pathological accumulation of these proteins.