Feasibility study of computed vs measured high b-value (1400 s/mm2) diffusion-weighted MR images of the prostate
Feasibility study of computed vs measured high b-value (1400 s/mm2) diffusion-weighted MR images of the prostate
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DOI：
10.4329/wjr.v6.i6.374
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发表时间：
2014-06-28
影响因子：
2.5
通讯作者：
Hausmann, Daniel
中科院分区：
文献类型：
--
作者：
Bittencourt, Leonardo K.;Attenberger, Ulrike I.;Hausmann, Daniel
目的：使用基于小视野序列（sFOV）的现代3 T-MR系统，评价计算的B = 1400 s/mm（2）（C-b 1400）与测量的B = 1400 s/mm（2）（M-b 1400）扩散加权图像（DWI）对病变检出率、图像质量和病变分界质量的影响。（PSA：9.5 +/- 8.7 ng/mL; 68 +/- 12岁），接受前列腺磁共振成像（MRI）。所有测量均在3 T MR系统上进行。DWI采用单次激发EPI扩散序列（B = 0、100、400、800 s/mm（2））。从ADC和扩散图像逐体素计算C-b1400。此外，还获得了M-b1400用于评价和比较。获得并比较病变检出率和最大病变直径。根据5分Likert类型量表对图像质量和病变分界质量进行评级。结果：M-b1400图像检出24个病灶，并与C-b1400图像进行比较。C-b1400检测到三个额外的癌症可疑病变。C-b1400的总体图像质量明显更好，SI比值明显更高（2.3 +/- 0.8 vs 3.1 +/- 1.0，P < 0.001; 5.6 +/- 1.8 vs 2.8 +/- 0.9，P < 0.001）。结论：结合高b值外推和sFOV可以在不增加采集时间的情况下提高DWI的诊断准确性，这可能有助于指导靶向前列腺活检并提高多参数MRI（mMRI）的质量，特别是在私人诊所环境中的经济方面。(c)2014百世登出版集团股份有限公司All rights reserved.
AIM: To evaluate the impact of computed b = 1400 s/mm(2) (C-b1400) vs measured b = 1400 s/mm(2) (M-b1400) diffusion-weighted images (DWI) on lesion detection rate, image quality and quality of lesion demarcation using a modern 3T-MR system based on a small-field-of-view sequence (sFOV).METHODS: Thirty patients (PSA: 9.5 +/- 8.7 ng/mL; 68 +/- 12 years) referred for magnetic resonance imaging (MRI) of the prostate were enrolled in this study. All measurements were performed on a 3T MR system. For DWI, a single-shot EPI diffusion sequence (b = 0, 100, 400, 800 s/mm (2)) was utilized. C-b1400 was calculated voxelwise from the ADC and diffusion images. Additionally, M-b1400 was acquired for evaluation and comparison. Lesion detection rate and maximum lesion diameters were obtained and compared. Image quality and quality of lesion demarcation were rated according to a 5-point Likert-type scale. Ratios of lesion-to-bladder as well as prostate-to-bladder signal intensity (SI) were calculated to estimate the signal-to-noiseratio (SNR).RESULTS: Twenty-four lesions were detected on M-b1400 images and compared to C-b1400 images. C-b1400 detected three additional cancer suspicious lesions. Overall image quality was rated significantly better and SI ratios were significantly higher on C-b1400 (2.3 +/- 0.8 vs 3.1 +/- 1.0, P < 0.001; 5.6 +/- 1.8 vs 2.8 +/- 0.9, P < 0.001). Comparison of lesion size showed no significant differences between C-and M-b1400 (P = 0.22).CONCLUSION: Combination of a high b-value extrapolation and sFOV may contribute to increase diagnostic accuracy of DWI without an increase of acquisition time, which may be useful to guide targeted prostate biopsies and to improve quality of multiparametric MRI (mMRI) especially under economical aspects in a private practice setting. (c) 2014 Baishideng Publishing Group Inc. All rights reserved.