"Wide local ablation" of localized breast cancer using high intensity focused ultrasound
"Wide local ablation" of localized breast cancer using high intensity focused ultrasound
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DOI：
10.1002/jso.20769
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发表时间：
2007-08-01
影响因子：
2.5
通讯作者：
Zou, Jiang-Zhong
中科院分区：
文献类型：
--
作者：
Wu, Feng;Wang, Zhi-Biao;Zou, Jiang-Zhong
背景与目的：高强度聚焦超声（HIFU）是一种无创性的肿瘤消融技术。本研究的目的是调查的可行性进行广泛的局部消融使用超声引导下的高强度聚焦超声在治疗局部乳腺癌的患者。方法：23例经组织学证实的乳腺癌患者参加了这项前瞻性临床试验。她们接受了乳腺癌的HIFU治疗，包括肿瘤和肿瘤周围1.5-2.0 cm的正常乳腺组织，然后在HIFU治疗后1-2周进行改良乳房切除术。放射学检查，组织学，和末端脱氧核苷酸转移酶介导的缺口末端标记（TUNEL）方法进行评估治疗region.Results的治疗效果：热消融证实在所有23例患者。它包括肿瘤和肿瘤周围的正常乳腺组织。切除乳腺的HIFU病灶最大平行、垂直径及体积的平均值均明显大于靶肿瘤（P < 0.001）。苏木精和伊红（H & E）染色显示治疗区域完全凝固性坏死的明显证据。结论：作为一种非侵入性治疗方法，超声引导下的高强度聚焦超声治疗局限性乳腺癌具有广泛的局部消融作用。
Background and Objective: High intensity focused ultrasound (HIFU) is a non-invasive technique for tumor ablation. The goal of this study was to investigate the feasibility of performing wide local ablation using ultrasound-guided HIFU in the treatment of patients with localized breast cancer.Methods: Twenty-three patients with histologically proven breast cancer were enrolled in this prospective clinical trial. They underwent HIFU treatment for breast cancer including the tumor and 1.5-2.0 cm normal breast tissue surrounding the tumor, followed by modified mastectomy 1-2 weeks after HIFU. Radiological examination, histological, and terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) methods were performed to evaluate therapeutic effects in the treated region.Results: Thermal ablation was confirmed in all 23 patients. It included tumor and normal breast tissue surrounding the tumor. Mean values of the largest parallel and perpendicular dimensions, and volume of HIFU lesions in excised breasts were significantly larger than those of the targeted tumors respectively (P < 0.001). Hematoxylin and eosin (H & E) staining showed clear evidence of complete coagulation necrosis in the treated regions. However, no apoptotic cells were detected in either treated tumor or normal breast tissue.Conclusion: As a non-invasive therapy, ultrasound-guided HIFU can induce wide local ablation in the treatment of patients with localized breast cancer.