Tryptophan metabolism in patients with breast cancer.
Tryptophan metabolism in patients with breast cancer.
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发表时间：
1985
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通讯作者：
P. Jm;Dickerson Jw;White Wf
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作者：
P. Jm;Dickerson Jw;White Wf
51名乳腺癌患者的血浆总色氨酸水平显著低于14名良性乳腺癌患者，手术后和12周后。肿瘤患者尿中黄尿酸和5-羟基吲哚乙酸的排泄量与良性疾病患者相似，但肿瘤患者尿中N '-甲基烟酰胺（NMN）的排泄量显著高于良性疾病患者（P <0.001）。这表明，NMN的尿排泄量增加是由于较高的NAD活性，反映了通过科里循环的糖酵解增加。
: Plasma levels of total tryptophan were significantly lower in 51 patients with breast cancer than in 14 women with benign breast cancer following surgery and after 12 weeks. The urinary excretion of xanthurenic and 5-hydroxyindoleacetic acids were similar in patients with cancer and benign disease but the excretion of N'-methylnicotinamide (NMN) was significantly higher (P less than 0.001) in the cancer patients. It is suggested that the elevated urinary excretions of NMN is due to higher NAD activity reflecting elevated glycolysis through the Cori cycle.