ROG, repressor of GATA, regulates the expression of cytokine genes
ROG, repressor of GATA, regulates the expression of cytokine genes
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DOI：
10.1016/s1074-7613(00)80185-5
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发表时间：
2000-03-01
期刊：
影响因子：
32.4
通讯作者：
Ho, IC
中科院分区：
文献类型：
--
作者：
Miaw, SC;Choi, A;Ho, IC
GATA-3是一种T细胞特异性转录因子，对T细胞谱系的发育至关重要。最近的研究表明，在CD4（+）辅助T细胞分化为2型效应细胞时，GATA-3的表达被进一步诱导，而不是1型效应细胞。在这里，我们报道了GATA-3相互作用蛋白，GATA抑制因子（ROG）的分子克隆。ROG是一种淋巴细胞特异性基因，在抗cd3刺激下在Th细胞中迅速诱导。在体外实验中，ROG抑制gata -3诱导的转激活。此外，在Th克隆中，ROG的过表达抑制了Th细胞因子的产生。综上所述，我们的研究结果表明，ROG可能在调节Th细胞的分化和激活中发挥关键作用。
GATA-3 is a T cell-specific transcription factor and is essential for the development of the T cell lineage. Recently, it was shown that the expression of GATA-3 is further induced in CD4(+) helper T cells upon differentiation into type 2 but not type 1 effector cells. Here, we report the molecular cloning of a GATA-3 interacting protein, repressor of GATA (ROG). ROG is a lymphoid-specific gene and is rapidly induced in Th cells upon stimulation with anti-CD3. In in vitro assays, ROG represses the GATA-3-induced transactivation. Furthermore, overexpression of ROG in Th clones inhibits the production of Th cytokines. Taken together, our results suggest that ROG might play a critical role in regulating the differentiation and activation of Th cells.