B-arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice
B-arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice
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DOI：
10.1359/jbmr.041204
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发表时间：
2005-04-01
影响因子：
6.2
通讯作者：
Ferrari, SL
中科院分区：
文献类型：
--
作者：
Bouxsein, ML;Pierroz, DD;Ferrari, SL
胞质阻滞剂在体外调节甲状旁腺素信号转导。我们发现雌性β-arrestin2(-/-)小鼠骨量减少，骨结构改变。间歇性给予甲状旁腺素对骨骼微结构的影响在β-arrestin2(-/-)和野生型小鼠中不同。这些数据表明，arrestin介导的细胞内信号调节有助于甲状旁腺素在骨内膜和骨膜表面的不同作用。
Cytoplasmic arrestins regulate PTH signaling in vitro. We show that female beta-arrestin2(-/-) mice have decreased bone mass and altered bone architecture. The effects of intermittent PTH administration on bone microarchitecture differed in beta-arrestin2(-/-) and wildtype mice. These data indicate that arrestin-mediated regulation of intracellular signaling contributes to the differential effects of PTH at endosteal and periosteal bone surfaces.