Efficacy of Azithromycin Eyedrops for Individuals With Meibomian Gland Dysfunction-Associated Posterior Blepharitis.
Efficacy of Azithromycin Eyedrops for Individuals With Meibomian Gland Dysfunction-Associated Posterior Blepharitis.
复制标题
DOI：
10.1097/icl.0000000000000729
复制
发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Fukuoka S
中科院分区：
文献类型：
--
作者：
Arita R;Fukuoka S
目的：探讨阿奇霉素滴眼液对日本睑板腺功能障碍（MGD）相关后睑炎患者的安全性和有效性。在日本埼玉县伊藤诊所就诊的mgd相关性后睑炎患者被随机分配接受阿奇霉素（1%）滴眼液（AZM组，16例患者的16只眼）或不含防腐剂的人工泪液（对照组，20例患者的20只眼）治疗2周。所有受试者还每天进行两次热敷眼睑。检测治疗前后主观症状（标准化患者眼干评价[SPEED]评分）、泪膜脂质层厚度（LLT）和干涉模式、眼睑边缘堵塞和血管状况、泪膜无创破裂时间（NIBUT）和基于荧光素的泪膜破裂时间（TBUT）、角膜-结膜荧光素染色评分、泪膜半月板高度、meibum分级、meiboscore、泪液渗透压和Schirmer试验值。同时记录了治疗的副作用。AZM组治疗后，SPEED评分、LLT、干涉模式、眼睑边缘堵塞和血管状况、NIBUT、TBUT、meibum分级和泪液渗透压均较基线显著改善。与对照组相比，AZM组治疗后的SPEED评分、干涉模式、堵塞、血管通畅、骨髓分级和泪液渗透压也有显著改善。AZM组常见的副作用是短暂的眼睛刺激和视力模糊。阿奇霉素滴眼液改善了眼睑炎症、泪膜脂质层的质和量，以及泪膜的稳定性。因此，这种眼药水似乎是一种安全有效的治疗mgd相关后睑炎的方法。
To examine the safety and efficacy of azithromycin eyedrops in Japanese individuals with meibomian gland dysfunction (MGD)-associated posterior blepharitis. Individuals with MGD-associated posterior blepharitis who visited the Itoh Clinic, Saitama, Japan, were randomly assigned to receive azithromycin (1%) eyedrops (AZM group, 16 eyes of 16 patients) or preservative-free artificial tears (control group, 20 eyes of 20 patients) for 2 weeks. All subjects also applied a warming eyelid compress twice per day. Subjective symptoms (Standardized Patient Evaluation of Eye Dryness [SPEED] score), lipid layer thickness (LLT) and interferometric pattern of the tear film, plugging and vascularity of the lid margin, noninvasive break-up time of the tear film (NIBUT) and fluorescein-based break-up time of the tear film (TBUT), corneal–conjunctival fluorescein staining score, tear meniscus height, meibum grade, meiboscore, tear osmolarity, and Schirmer test value were determined before and after treatment. Side effects of treatment were also recorded. In the AZM group, SPEED score, LLT, interferometric pattern, plugging and vascularity of the lid margin, NIBUT, TBUT, meibum grade, and tear osmolarity were significantly improved after treatment compared with baseline. The SPEED score, interferometric pattern, plugging, vascularity, meibum grade, and tear osmolarity were also significantly improved after treatment in the AZM group compared with the control group. Common side effects in the AZM group were transient eye irritation and blurred vision. Azithromycin eyedrops improved eyelid inflammation, the quality and quantity of the lipid layer of the tear film, and tear film stability. Such eyedrops thus seem to be a safe and effective treatment for MGD-associated posterior blepharitis.