Nerve growth factor: basic studies and possible therapeutic applications
Nerve growth factor: basic studies and possible therapeutic applications
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DOI：
10.3109/08977194.2013.804073
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发表时间：
2013-08-01
期刊：
影响因子：
1.8
通讯作者：
Aloe, Luigi
中科院分区：
文献类型：
--
作者：
Manni, Luigi;Rocco, Maria Luisa;Aloe, Luigi
神经生长因子（NGF）属于神经营养因子家族，称为神经营养因子。它被发现是一种刺激周围神经系统中发育神经元存活和成熟的分子，后来被证明可以保护退化哺乳动物大脑中的成年神经元。已经进行了基础和临床研究，以使用NGF作为治疗剂，旨在恢复和维持中枢神经系统中的神经元功能，并确定将分子安全地递送到脑中的机制。最近的研究还认识到，神经生长因子的作用远远超出了神经细胞的范围，甚至超出了外周和中枢神经系统。我们实验室发表的研究表明，局部应用NGF对人类压力性溃疡、角膜溃疡和青光眼具有保护作用。在这里，我们将回顾这些研究，支持神经生长因子的治疗潜力。
The nerve growth factor (NGF) belongs to a family of neurotrophic factors called neurotrophins. It was discovered as a molecule that stimulates the survival and maturation of developing neurons in the peripheral nervous system and has later been shown to protect adult neurons in the degenerating mammalian brain. Basic and clinical studies have been undertaken to use NGF as a therapeutic agent aimed at restoring and maintaining neuronal function in the central nervous system and to determine the mechanisms to safely deliver the molecule into the brain. Recent studies have also recognized that the role of NGF extends far beyond the horizon of nerve cells and even beyond the peripheral and central nervous system. Studies published from our laboratory have shown that topical application of NGF possesses a protective action on human pressure ulcer, corneal ulcer and glaucoma. Here, we will review these studies, supporting the therapeutic potential of NGF.