Hippocampal Abnormalities in Youth with Alcohol-Related Neurodevelopmental Disorder
Hippocampal Abnormalities in Youth with Alcohol-Related Neurodevelopmental Disorder
复制标题
DOI：
10.1017/s1355617713001343
复制
发表时间：
2014-02-01
影响因子：
2.6
通讯作者：
Rovet, Joanne
中科院分区：
文献类型：
--
作者：
Dudek, Joanna;Skocic, Jovanka;Rovet, Joanne
被诊断为酒精相关神经发育障碍(ARND)的个体在海马体介导的记忆任务中表现出困难，并表现出海马体大小减小。然而，关于受影响的记忆功能和海马体效应发生在哪里，存在着不一致的看法。鉴于最近的研究表明，前节和后节支持不同的记忆功能和海马区功能的性别二型性，我们询问这些因素是否影响患有ARND的青年(n=18)和典型发育对照组(n=17)的记忆表现。参与者接受了一系列记忆测试和结构性核磁共振扫描。手动追踪右侧和左侧海马区；在钩部勾画出前段和后段。测量的是颅内体积(ICV)以及左右两侧的海马区和海马区。调整了ICV的音量。与对照组相比，ARND组在大多数任务上的智商和记忆表现较低，ICV略小。ARND组大鼠左右侧海马区体积和后节均较小。虽然不同组之间没有性别差异，但女性总体上比男性有更大的前海马区。仅在ARND组中，海马区与选择记忆指数之间存在正相关和负相关。这些发现首次表明，患有ARND的青年患者的海马区后部发育可能受到损害。(JINS，2014，20,181-191)
Individuals diagnosed with alcohol-related neurodevelopmental disorder (ARND) exhibit difficulty on hippocampally mediated memory tasks and show reduced hippocampal size. However inconsistencies exist regarding the affected memory functions and where within the hippocampi effects occur. Given recent studies showing anterior and posterior segments support distinct memory functions and sex dimorphisms in hippocampal function, we asked whether these factors influence memory performance in youth with ARND (n = 18) and typically developing controls (n = 17). Participants received a battery of memory tests and a structural MRI scan. Right and left hippocampi were manually traced; anterior and posterior segments were delineated at the uncus. Measured were intracranial volumes (ICV) and right and left hippocampi and hippocampal segments. Volumes were adjusted for ICV. Relative to controls, the ARND group had lower IQs and memory performance on most tasks and marginally smaller ICVs. Left and right hippocampal volumes and posterior segments were smaller in the ARND group. Although no sex differences were observed between groups, females overall had larger anterior hippocampi than males. Positive and negative associations between hippocampal and selective memory indices were found in the ARND group only. These findings are the first to suggest that posterior hippocampal development may be compromised in youth with ARND. (JINS, 2014, 20, 181-191)