Regulatory roles of microRNAs in insect pests: prospective targets for insect pest control
Regulatory roles of microRNAs in insect pests: prospective targets for insect pest control
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microRNA在害虫中的调节作用：害虫防治的前瞻性目标
DOI：
10.1016/j.copbio.2021.05.002
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发表时间：
2021
影响因子：
7.7
通讯作者：
Wang Jin-Jun
中科院分区：
文献类型：
--
作者：
Zhang Qiang;Dou Wei;Taning Clauvis Nji Tizi;Smagghe Guy;Wang Jin-Jun
miRNAs在昆虫中发挥着转录后水平的调控作用。miRNAs是昆虫发育的关键介质，参与杀虫剂抗性和寄主适应。miRNAs是害虫防治的一个有前景的靶标。转基因生物技术是miRNAs应用的有效解决方案。在转录后水平，microRNAs（miRNAs）在基因表达调控中发挥着重要作用，从而影响昆虫的许多生物过程的结果，例如发育、生殖、变态、免疫和杀虫剂抗性。通过注射/喂食的mimic/agomir或inhibitor/peptidomir改变miRNA表达可导致害虫发育异常、死亡或杀虫剂抗性降低，表明miRNA是害虫控制的潜在靶标。本文综述了miRNA在农业和公共卫生害虫中的调控作用，并进一步强调了miRNA作为害虫控制靶点的潜力。
HighlightsmiRNAs play regulatory roles at the post-transcriptional level in insects.miRNAs as key mediators in insect development.miRNAs participate in insecticide resistance and host adaptation.miRNAs as a prospective target in pest control.Transgenic biotechnology is an effective solution for miRNAs application.At the post-transcriptional level, microRNAs (miRNAs) play an important role in the regulation of gene expression, thereby influencing the outcome of many biological processes in insects, such as development, reproduction, metamorphosis, immunity, and insecticide resistance. The alteration of miRNA expression by mimic/agomir or inhibitor/antagomir via injection/feeding can lead to pest developmental abnormalities, death, or reduced pesticide resistance, indicating that miRNAs are potential targets for pest control. This review provides an overview of recent advances in understanding the regulatory roles of miRNA in agricultural and public health insect pest, and further highlights the potential of miRNAs as prospective targets in pest control.