MESOLIMBIC AND MESOCORTICAL DOPAMINE ACTIVATION INDUCED BY PHENCYCLIDINE - CONTRASTING PATTERN TO STRIATAL RESPONSE
MESOLIMBIC AND MESOCORTICAL DOPAMINE ACTIVATION INDUCED BY PHENCYCLIDINE - CONTRASTING PATTERN TO STRIATAL RESPONSE
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DOI：
10.1016/0014-2999(87)90356-6
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发表时间：
1987-02-24
影响因子：
5
通讯作者：
ROTH, RH
中科院分区：
文献类型：
--
作者：
DEUTCH, AY;TAM, SY;ROTH, RH
苯环利定，一种间接的多巴胺受体激动剂，对多巴胺能激活的生化指标的影响进行了研究，在中皮层，中脑边缘和黑质纹状体区域的大鼠。高剂量（10 mg/kg）的苯环利定导致在所有的mesolimbic和mesocortical网站检查，以及在腹侧被盖区，源的多巴胺能神经支配的mesolimbic/皮质网站的多巴胺代谢产物3，4-二羟基苯乙酸和高香草酸的水平显着增加。相反，两种代谢物的水平在纹状体中降低，并且在黑质中倾向于降低，黑质是纹状体多巴胺能神经支配的来源。代谢产物对苯环利定的反应与剂量相关。这些数据表明，中脑边缘和中皮层多巴胺能神经元被苯环利定激活。由于发射率的A10（腹侧被盖区）和A9（黑质）多巴胺神经元已被证明是增加苯环利定，这些数据表明，苯环利定的结果在一个差异调节突触前释放的多巴胺在中脑边缘/皮层，而不是黑质纹状体多巴胺能区域。
The effects of acute administration of phencyclidine, an indirect dopamine agonist, on biochemical indices of dopaminergic activation were examined in mesocortical, mesolimbic and nigrostriatal regions of the rat. High doses (10 mg/kg) of phencyclidine resulted in a marked increase in levels of the dopamine metabolites 3,4-dihydroxyphenyl-acetic acid and homovanillic acid in all mesolimbic and mesocortical sites examined, as well as in the ventral tegmental area, source of the dopaminergic innervation of mesolimbic/cortical sites. In contrast, levels of both metabolites decreased in the striatum and tended to decrease in the substantia nigra, source of the striatal dopaminergic innervation. The metabolite response to phencyclidine was dose-related. These data indicate that the mesolimbic and mesocortical dopaminergic neurons are activated by phencyclidine. Since the firing rate of both A10 (ventral tegmental area) and A9 (substantia nigra) dopamine neurons has previously been shown to be increased by phencyclidine, these data suggest that phencyclidine results in a differential regulation of presynaptic release of dopamine in mesolimbic/cortical as opposed to nigrostriatal dopaminergic regions.