Mesangial pathology in glomerular disease: targets for therapeutic intervention.
Mesangial pathology in glomerular disease: targets for therapeutic intervention.
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DOI：
10.1016/j.addr.2010.08.011
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发表时间：
2010-11-30
影响因子：
16.1
通讯作者：
Bagavant, Harini
中科院分区：
文献类型：
--
作者：
Scindia, Yogesh M.;Deshmukh, Umesh S.;Bagavant, Harini
肾小球是肾脏的过滤单位。肾小球功能的破坏可能是由原发性肾小球病变或继发于全身性疾病引起的。肾小球的系膜细胞、内皮细胞和上皮细胞参与大多数病理过程。动物模型提供了肾小球疾病的分子基础的理解。这些研究表明，系膜细胞在疾病的发生和发展中起着关键作用。因此，调节系膜细胞反应提供了一种新的治疗方法。肾脏，特别是肾小球的复杂结构使得靶向药物递送特别具有挑战性。治疗剂的靶向递送减少了给药剂量并使由对其他组织的毒性引起的不希望的副作用最小化。目前可用的方式证明肾小球系膜细胞靶向的可行性进行了讨论。
The glomerulus is the filtration unit of the kidney. Disruption of glomerular function may be caused by primary glomerular pathology or secondary to systemic diseases. The mesangial, endothelial and epithelial cells of the glomerulus are involved in most pathologic processes. Animal models provide an understanding of the molecular basis of glomerular disease. These studies show that mesangial cells are critical players in initiation and progression of disease. Therefore, modulation of mesangial cell responses offers a novel therapeutic approach. The complex architecture of the kidney, specifically the renal glomerulus makes targeted drug delivery especially challenging. Targeted delivery of therapeutic agents reduces dose of administration and minimizes unwanted side effects caused by toxicity to other tissues. The currently available modalities demonstrating the feasibility of mesangial cell targeting are discussed.
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DOI：
10.1111/j.1600-0714.2008.00700.x
发表时间：
2009-01
期刊：
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
影响因子：
--
作者：
Deshmukh US;Nandula SR;Thimmalapura PR;Scindia YM;Bagavant H
通讯作者：
Bagavant H
影响因子：
5.1
作者：
Bagavant H;Fu SM
通讯作者：
Fu SM
影响因子：
3.7
作者：
Harigai, T;Kondo, M;Kimura, J
通讯作者：
Kimura, J
影响因子：
19.6
作者：
Coppo, Rosanna;Fonsato, Valentina;Camussi, Giovanni
通讯作者：
Camussi, Giovanni
影响因子：
4.4
作者：
Bagavant, H;Thompson, C;Tung, KSK
通讯作者：
Tung, KSK