Unraveling the Role of Allo-Antibodies and Transplant Injury.
Unraveling the Role of Allo-Antibodies and Transplant Injury.
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DOI：
10.3389/fimmu.2016.00432
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发表时间：
2016
影响因子：
7.3
通讯作者：
Sarwal MM
中科院分区：
文献类型：
--
作者：
Matsuda Y;Sarwal MM
在实体器官移植中，同种异体免疫驱动的排斥反应可以大致分为主要由T细胞介导的排斥反应（TCMR）和抗体介导的排斥反应（ABMR）驱动的机制，尽管在不同数量的移植物样本中可以看到两种类型的排斥反应共存。通过建立有效的免疫抑制机制，一般可以很好地控制急性TCMR。在血型和HLA供体/受体匹配以及在高滴度、预先形成的供体特异性抗体避免移植的背景下，急性ABMR是一种低频率的发现。然而，慢性ABMR仍然是导致移植器官过早丢失的主要并发症。人类白细胞抗原（HLA）抗体的高灵敏度检测揭示了供体特异性抗体与ABMR之间的密切关系。在HLA相同的移植和供体特异性抗体缺失的情况下，体液免疫反应激活对移植器官的损伤（17-24）强烈提示非HLA （nHLA）抗体参与ABMR（25）。在这篇综述中，我们讨论了在HLA和nHLA抗体的背景下ABMR的起源，并总结了ABMR的管理策略。
Alloimmunity driving rejection in the context of solid organ transplantation can be grossly divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), though the co-existence of both types of rejections can be seen in a variable number of sampled grafts. Acute TCMR can generally be well controlled by the establishment of effective immunosuppression. Acute ABMR is a low frequency finding in the current era of blood group and HLA donor/recipient matching and the avoidance of engraftment in the context of high-titer, preformed donor-specific antibodies. However, chronic ABMR remains a major complication resulting in the untimely loss of transplanted organs. The close relationship between donor-specific antibodies and ABMR has been revealed by the highly sensitive detection of human leukocyte antigen (HLA) antibodies. Injury to transplanted organs by activation of humoral immune reaction in the context of HLA identical transplants and the absence of donor specific antibodies (17–24), strongly suggest the participation of non-HLA (nHLA) antibodies in ABMR (25). In this review, we discuss the genesis of ABMR in the context of HLA and nHLA antibodies and summarize strategies for ABMR management.
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影响因子：
1.5
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
Cerottini, J C;Brunner, K T
通讯作者：
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