Incidence of peripheral neuropathy and cerebellar ataxia in chronic alcoholics
Incidence of peripheral neuropathy and cerebellar ataxia in chronic alcoholics
复制标题
慢性酗酒者周围神经病变和小脑共济失调的发生率
作者：
E. Scholz;H. Diener;J. Dichgans;H. Langohr;W. Schied;A. Schupmann
本文对78例慢性酒精中毒者进行了神经功能、神经电图、肌电图和姿势图检查。45%的患者有周围神经病变的临床表现，67%的患者有肌电图异常，55%的患者有神经电图异常。33%的患者出现小脑共济失调的临床症状，而69%的患者记录到增加的摇摆的姿势图测量。在后者三分之二的患者中观察到了小脑前叶萎缩的姿势图特征。小脑性共济失调的严重程度与神经病变的程度无关。这种相关性的缺乏被解释为不同的发病机制作用于周围神经和小脑的指示。
SummaryA total of 78 chronic alcoholics were examined neurologically as well as by electroneurography, myography and posturography. Clinical signs of peripheral neuropathy were detected in 45% of these patients, with electromyographic and neurographic abnormality in 67% and 55% respectively. Clinical signs of cerebellar ataxia were found in 33% of our patients, whereas posturographic measurements of increased sway were recorded in 69%. The posturographic characteristics of cerebellar anterior lobe atrophy were observed in two-thirds of the latter patients. The severity of cerebellar-ataxia did not correlate with the degree of neuropathy. This lack of correlation is interpreted as an indication of different pathogenetic mechanisms acting on peripheral nerves and cerebellum.