Determining the waist circumference in African Americans which best predicts insulin resistance

Determining the waist circumference in African Americans which best predicts insulin resistance
复制标题

DOI：
10.1038/oby.2008.11
复制
发表时间：
2008-04-01
期刊：
OBESITY
影响因子：
6.9
通讯作者：
Kushner, Harvey
Kushner, Harvey
中科院分区：
医学2区
文献类型：
--
作者：
Sumner, Anne E.;Sen, Sabyasachi;Kushner, Harvey

文献摘要

被引文献

相似文献

总体尺寸和中央脂肪分布是胰岛素抵抗的重要决定因素。非裔美国人最能预测胰岛素抵抗的 BMI 和腰围 (WC) 阈值尚不清楚。我们的目标是确定非裔美国人的 BMI 和 WC 值，以最佳地预测胰岛素抵抗。受试者为非裔美国人（68 名男性，63 名女性），年龄 35 +/- 8 岁（平均值 +/- s.d.），BMI 为 30.9 +/- 7.5，范围为 18.5-54.7 kg/m(2)，WC 为 98 +/- 18，范围为 69-173 cm。胰岛素抵抗由胰岛素敏感性指数（S-I）的最低三分位数定义。计算约登指数以确定 WC 和 BMI 阈值，以最佳的灵敏度和特异性组合预测胰岛素抵抗。在男性中，最佳预测胰岛素抵抗的阈值是 BMI >= 30 kg/m(2) 或 WC >= 102 cm。对于女性来说，最好通过 BMI >= 32 kg/m(2) 或 WC >= 98 cm 来预测胰岛素抵抗。在非裔美国人中，胰岛素抵抗（男性）最好通过 WC >= 102 cm 来预测，对于女性来说，通过 WC >= 98 cm 或属于肥胖类别的 BMI 值（男性：= 30 kg/ m(2)，女性：= 32 kg/ m(2)）来预测胰岛素抵抗。
Total body size and central fat distribution are important determinants of insulin resistance. The BMI and waist circumference ( WC) thresholds in African Americans that best predict insulin resistance are unknown. Our goal was to determine the BMI and WC values in African Americans, which optimally predict insulin resistance. The subjects were African Americans ( 68 men, 63 women), aged 35 +/- 8 years ( mean +/- s.d.), with a BMI of 30.9 +/- 7.5, in the range of 18.5-54.7 kg/m(2), and with a WC of 98 +/- 18, in the range of 69-173 cm. Insulin resistance was defined by the lowest tertile of the insulin sensitivity index ( S-I). The Youden index was calculated to determine the WC and BMI thresholds that predict insulin resistance with an optimal combination of sensitivity and specificity. In men the thresholds that optimally predicted insulin resistance were a BMI >= 30 kg/m(2) or a WC >= 102 cm. For women, insulin resistance was best predicted by a BMI >= 32 kg/ m(2) or a WC >= 98 cm. In African Americans, insulin resistance ( in men) was best predicted by a WC >= 102 cm, and in women by a WC >= 98 cm, or by a BMI value that fell in the obese category ( men: = 30 kg/ m(2), women: = 32 kg/ m(2)).