Maternal periodontal status and preterm delivery: a hospital based case-control study
Maternal periodontal status and preterm delivery: a hospital based case-control study
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DOI：
10.1111/j.1600-0765.2011.01371.x
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发表时间：
2011-10-01
影响因子：
3.5
通讯作者：
Kutty, V. R.
中科院分区：
文献类型：
--
作者：
Baskaradoss, J. K.;Geevarghese, A.;Kutty, V. R.
背景和目的：最近的研究表明，孕妇的牙周病可能是早产的一个决定因素。然而，这一发现并没有得到始终如一的观察。本研究旨在探讨印度喀拉拉邦孕妇牙周病与早产的关系。材料和方法：病例对照研究以300名18岁以上的产后妇女为研究对象(100名病例和200名对照)。研究对象为自然早产(妊娠37周)的妇女，对照组为足月分娩的妇女(妊娠37周)。在产科病房进行标准、临床和牙周检查，并通过多因素Logistic回归模型评估牙周病与早产之间的相关性。结果：病例组和对照组母亲牙周炎的患病率分别为25%和14.5%。Logistic回归分析表明，患有牙周炎的母亲早产的风险几乎是母亲的三倍[调整后的优势比(ORA)=2.72；95%可信区间(CI)：1.68-6.84]。体力消耗(OR a=2.80；95%CI：1.18~6.65)、既往早产史(OR a=2.65；95%CI：1.20~5.83)和婴儿流产/死亡史(OR a=4.08；95%CI：1.56~10.65)是早产的危险因素。
Background and Objective: Recent studies have presented evidence that periodontal disease in pregnant women may be a determining factor for preterm delivery. However, this finding has not been consistently observed. The present investigation was carried out to explore the association between maternal periodontal disease and preterm delivery in the state of Kerala, India.Material and Methods: The case-control study had a sample of 300 (100 cases and 200 controls) postpartum women over 18 years of age. Cases were women who had undergone spontaneous preterm delivery (< 37 wk of gestation) and controls were women who delivered at term (>= 37 wk of gestation). Standard, clinical and periodontal examinations were performed at the maternity wards, and the existence of an association between periodontal disease and preterm delivery was evaluated by means of a multivariate logistic regression model that also considered other risk factors for preterm delivery.Results: Periodontitis was diagnosed in 25% of the mothers in the case group and in 14.5% of the mothers in the control group. Logistic regression analysis indicated a risk of nearly threefold for preterm delivery in mothers with periodontitis [ adjusted odds ratio (ORa) = 2.72; 95% confidence interval (CI): 1.68-6.84]. The other factors significantly associated with preterm birth were physical exertion (OR a = 2.80; 95% CI: 1.18-6.65), a previous history of preterm birth (ORa = 2.65; 95% CI: 1.20-5.83) and previous abortion/death of infant (OR a = 4.08; 95% CI: 1.56-10.65).Conclusion: Periodontal disease is a possible risk factor for preterm delivery in this population.