Electrical stimulation of human fusiform face-selective regions distorts face perception.
Electrical stimulation of human fusiform face-selective regions distorts face perception.
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DOI：
10.1523/jneurosci.2609-12.2012
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发表时间：
2012-10-24
期刊：
影响因子：
--
通讯作者：
Grill-Spector K
中科院分区：
文献类型：
--
作者：
Parvizi J;Jacques C;Foster BL;Witthoft N;Rangarajan V;Weiner KS;Grill-Spector K
人类梭形回的面部选择性神经反应已被广泛研究。然而，它们在人脸感知中的因果作用在很大程度上是未知的。在这里，我们使用皮层脑电(ECoG)、高分辨率功能磁共振成像(FMRI)和脑电刺激(EBS)的多模式方法，直接研究了在右下颞叶植入硬膜下电极的患者，梭形回(FG)的面部选择性神经反应在面部感知中的因果作用。高分辨率fMRI发现了两个不同的FG面部选择性区域(mFus-Faces和pFus-Faces)。ECOG显示了与fMRI数据惊人的解剖和功能对应，其中一对脸部选择电极，相隔一厘米，分别重叠mFus-Faces和pFus-Faces。此外，传输到这对电极的电荷在观看真实面孔时会导致深刻的特定于面孔的感知扭曲。具体地说，受试者报告说，房间里的人的脸都变了样。有几个控制说明了这种影响对面孔感知的特异性。MFus-Faces和pFus-Faces的eBS在命名计算机上著名面孔的图片时既没有产生显著的缺陷，也没有影响非面孔对象的外观。此外，在假刺激和附近一对非面部选择性电极的刺激过程中，面部的外观都没有受到影响。总体而言，我们的发现揭示了fMRI、ECoG和EBS的惊人融合，它们一起在人类FG网络的功能子集和面孔感知之间提供了罕见的因果联系。
Face-selective neural responses in the human fusiform gyrus have been widely examined. However, their causal role in human face perception is largely unknown. Here, we used a multimodal approach of electrocorticography (ECoG), high-resolution functional magnetic resonance imaging (fMRI), and electrical brain stimulation (EBS) to directly investigate the causal role of face-selective neural responses of the fusiform gyrus (FG) in face perception in a patient implanted with subdural electrodes in the right inferior temporal lobe. High-resolution fMRI identified two distinct FG face-selective regions (mFus-faces and pFus-faces). ECoG revealed a striking anatomical and functional correspondence with fMRI data where a pair of face-selective electrodes, positioned one centimeter apart, overlapped mFus-faces and pFus-faces, respectively. Moreover, electrical charge delivered to this pair of electrodes induced a profound face-specific perceptual distortion during viewing of real faces. Specifically, the subject reported a “metamorphosed” appearance of faces of people in the room. Several controls illustrate the specificity of the effect to the perception of faces. EBS of mFus-faces and pFus-faces neither produced a significant deficit in naming pictures of famous faces on the computer, nor did it affect the appearance of nonface objects. Further, the appearance of faces remained unaffected during both sham stimulation and stimulation of a pair of nearby electrodes that were not face-selective. Overall, our findings reveal a striking convergence of fMRI, ECoG, and EBS, which together offer a rare causal link between functional subsets of the human FG network and face perception.