Association between low-grade albuminuria and hearing impairment in a non-diabetic Korean population: The Korea National Health and Nutrition Examination Survey (2011-2013)
Association between low-grade albuminuria and hearing impairment in a non-diabetic Korean population: The Korea National Health and Nutrition Examination Survey (2011-2013)
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DOI：
10.3109/07853890.2015.1093163
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发表时间：
2015-01-01
影响因子：
4.4
通讯作者：
Do, Jun Young
中科院分区：
文献类型：
--
作者：
Kang, Seok Hui;Jung, Da Jung;Do, Jun Young
介绍本研究的目的是探讨低度白蛋白尿和听力障碍之间的关联在non-diabetic population.Materials和方法的数据，从韩国国家健康和营养检查调查2011-2013年的分析。如果参与者年龄小于19岁，或尿白蛋白/肌酐比值（UACR）>= 30 mg/g或患有糖尿病，则将其从本研究中排除。共有10608名参与者参与了这项研究。结果低、中、高三分位组分别有男性1560、1561、1552人，女性1982、1975、1978人。结果表明，低度白蛋白尿与代谢综合征（MetS）组分或Fragrance风险评分的数量，以及MetS的存在或高心血管风险参与者的比例之间存在相关性。单变量和多变量线性回归分析表明，UACR和平均听阈（AHT）之间的关联，观察到在两种性别。多变量分析显示，低、中、高三分位组的平均AHT分别为：男性16.127 dB、17.139 dB和18.604 dB，女性14.842 dB、15.100 dB和16.353 dB。低频，中频和高频听力阈值根据UACR三分位数显示出类似的趋势。在这两种性别，多变量Logistic回归分析显示，在低和中三分位组的参与者有听力损失的风险降低相比，在高三分位group.Conclusion低级别白蛋白尿与听力损伤的非糖尿病参与者的这项研究。
Introduction The objective of the present study was to examine the association between low-grade albuminuria and hearing impairment in the non-diabetic population.Materials and methods Data from the Korean National Health and Nutrition Examination Survey 2011-2013 were used in the analyses. Participants were excluded from this study if they were younger than 19 years old, or had urine albumin/creatinine ratio (UACR) >= 30 mg/g or diabetes mellitus. There were 10 608 participants included in this study. The participants were divided into three groups according to their UACR tertiles.Results There were 1560; 1561; and 1552 male and 1982; 1975; and 1978, female participants in the low, middle, and high tertile groups, respectively. The results indicated the association between low-grade albuminuria and the numbers of metabolic syndrome (MetS) components or Framingham risk score, and the presence of MetS or the proportions of participants at high cardiovascular risk. Univariate and multivariate linear regression analyses demonstrated an association between the UACR and average hearing threshold (AHT) that was observed in both sexes. Multivariate analyses showed that mean AHTs in the low, middle, and high tertile groups were, respectively, 16.127 dB, 17.139 dB, and 18.604 dB for men, and 14.842 dB, 15.100 dB, and 16.353 dB, respectively, for women. Low-frequency, mid-frequency, and high-frequency hearing thresholds according to UACR tertiles showed similar trends. In both sexes, multivariate logistic regression analyses revealed that participants in the low and middle tertile groups had a decreased risk for hearing loss compared to participants in the high tertile group.Conclusion Low-grade albuminuria was associated with hearing impairment in the non-diabetic participants of this study.