USEFULNESS OF SERUM LYSOZYME MEASUREMENT IN DIAGNOSIS AND EVALUATION OF SARCOIDOSIS
USEFULNESS OF SERUM LYSOZYME MEASUREMENT IN DIAGNOSIS AND EVALUATION OF SARCOIDOSIS
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DOI：
10.1056/nejm197311152892007
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发表时间：
1973-01-01
影响因子：
158.5
通讯作者：
FINCH, SC
中科院分区：
文献类型：
--
作者：
PASCUAL, RS;GEE, JBL;FINCH, SC
溶菌酶是一种低分子量溶酶体酶，抗菌特性有限。相对较高的浓度出现在多形核白细胞和单核细胞中，1,2 大部分酶可能源自其中。3,4 血清和尿溶菌酶测定可用于区分髓细胞性白血病和单核细胞白血病与淋巴细胞白血病。123 患有急性细菌感染、类白血病反应、巨幼细胞贫血、中性粒细胞减少症相关疾病的患者中，血清溶菌酶活性会出现轻度至中度升高。伴有粒细胞周转增加和氮质血症。3,567此外，当血清活性高或肾小管损伤时，尿液中经常存在溶菌酶。1,2,7有多种理由表明血清溶菌酶。 。 。
LYSOZYME, a low-molecular-weight lysosomal enzyme, has limited antibacterial properties. Relatively high concentrations occur in polymorphonuclear leukocytes and monocytes,1,2from which most of the enzyme probably derives.3,4Assay of serum and urinary lysozyme is useful to distinguish myeloid and monocytic leukemias from lymphocytic leukemia.123A slight to moderate increase in serum lysozyme activity occurs in patients with acute bacterial infections, leukemoid reactions, megaloblastic anemias, neutropenic disorders associated with increased granulocyte turnover and azotemia.3,567In addition, lysozyme is frequently present in the urine when there is high serum activity or renal tubular damage.1,2,7There are several reasons to suggest that serum lysozyme . . .