The incidence and temporal patterning of insomnia: a pilot study.
The incidence and temporal patterning of insomnia: a pilot study.
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DOI：
10.1111/j.1365-2869.2009.00768.x
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发表时间：
2010-03
影响因子：
4.4
通讯作者：
Jungquist CR
中科院分区：
文献类型：
--
作者：
Perlis ML;Swinkels CM;Gehrman PR;Pigeon WR;Matteson-Rusby SE;Jungquist CR
迄今为止，对于失眠发生率的夜间变异性进行的研究还很少。先前的研究尚不清楚原发性失眠 (PI) 受试者是否在某个时间间隔内表现出良好的睡眠（或优于平均睡眠）。在本研究中，提供了以下方面的试点数据：1) PI 受试者“良好睡眠”发生的频率；2) 这些事件是否以非随机方式发生。 10 名 PI 受试者参与了这项“自然主义”研究。所有受试者都完成了至少 20 天的每日睡眠日记。在监测期间，没有受试者接受失眠治疗。通过将每晚的睡眠键入“好”或“坏”，然后确定每个受试者在良好的夜晚之前发生的糟糕夜晚的数量来评估今晚的数据。好的和糟糕的夜晚以两种方式分类：1. 使用 ≥ 85% 的截止值；2. 使用优于个人平均睡眠效率的值（具体截止值）。在评估的夜晚中，受试者的睡眠质量在 29%（> 85% 标准）和 55%（具体标准）之间。时间模式分析（基于具体截止值）显示，在一到三个晚上的睡眠不佳之后，最常见的情况是睡眠质量好于平均水平（> 89% 的情况）。这些数据表明，失眠的严重程度可能是由睡眠稳态介导/调节的，并且原发性失眠患者的稳态或稳态输入可能异常。
To date very little research has been conducted on night-to-night variability in the incidence of insomnia. Unclear from prior research is whether subjects with Primary Insomnia (PI) exhibit good sleep (or better than average sleep) on some interval basis. In the present study, pilot data are provided on 1) the frequency with which “good sleep” occurs in subjects with PI and 2) whether these events occur in a non-random manner. 10 PI subjects participated in this “naturalistic” study. All subjects completed daily sleep diaries for a minimum of 20 days. None of the subjects received treatment for their insomnia during the monitoring period. The night-tonight data were evaluated by typing each night’s sleep as “Good” or “Bad” and then by determining the number of bad nights that occurred prior to a good night for each subject. Good and bad nights were typed in two ways: 1. using a ≥ 85% cutoff and 2. using a better than the individual’s mean sleep efficiency (idiographic cutoff). Subjects exhibited good sleep on between 29% (> 85% criteria) and 55% (idiographic criteria) of the nights evaluated. The temporal patterning analysis (based on a idiographic cutoff) revealed that better than average sleep most frequently occurred (> 89% of instances) following one to three night’s of poor sleep. These data suggests that insomnia severity may be mediated/moderated by sleep homeostasis and that the homeostat, or input to the homeostat, may be abnormal in patients with Primary Insomnia.