Air pollution in asthma: effect of pollutants on airway inflammation
Air pollution in asthma: effect of pollutants on airway inflammation
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DOI：
10.1016/s1081-1206(10)62334-4
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发表时间：
2001-12-01
影响因子：
5.9
通讯作者：
Peden, DB
中科院分区：
文献类型：
--
作者：
Peden, DB
目的：本综述的目的是研究空气污染物对气道炎症的影响，重点是臭氧、颗粒物和内毒素暴露与免疫球蛋白e介导的气道炎症的相互作用。数据来源：本综述审查了国家环境空气质量标准和不同类型空气污染的来源，并对解决空气污染物对哮喘和过敏性炎症影响的流行病学和人类挑战研究进行了综述。结果：流行病学和人体挑战研究都表明，臭氧和内毒素暴露可加剧气道的过敏性炎症。相反，过敏过程也可能增强个体对空气污染物的反应。结论：臭氧和颗粒物都是诱发哮喘加重的重要因素。然而，这些污染物并没有涉及到免疫球蛋白E对新抗原反应的发展。减少这些污染物的暴露或更好地了解它们影响气道的过程可能有助于降低哮喘的严重程度。
Objectives: The objective of this review is to examine the impact of air pullutants on airway inflammation, with an emphasis on the interaction of the effect of ozone, particulate matter, and endotoxin exposure and immunoglobulin E-mediated airway inflammation.Data Sources: This review examines the National Ambient Air Quality Standards and sources for different types of air pollution, as well as undertaken a review of epidemiologic and human challenge studies which address the impact of air contaminants in asthma and allergic inflammation.Results: Epidemiologic and human challenge studies both demonstrate that ozone and endotoxin exposure can exacerbate allergic inflammation in the airway. Conversely, allergic processes may enhance individual response to air pollutants as well.Conclusions: Ozone and particulate matter are both important agents in inducing asthma exacerbation. However, these pollutants have not been implicated in development of immunoglobulin E responses to neoantigens. Decreased exposure to these pollutants or a better understanding of the processes by which they impact the airway may be useful in decreasing asthma severity.