Television watching and colorectal cancer survival in men.
Television watching and colorectal cancer survival in men.
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DOI：
10.1007/s10552-015-0645-x
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Giovannucci EL
中科院分区：
文献类型：
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作者：
Cao Y;Meyerhardt JA;Chan AT;Wu K;Fuchs CS;Giovannucci EL
评估诊断前和诊断后坐着看电视的时间以及其他久坐行为(其他坐在家里和工作中/开车)与结直肠癌或其他原因死亡率和总死亡率之间的关系。我们从卫生专业人员的随访研究(1986-2010)跟踪了I-III期结直肠癌患者。用COX模型计算危险比(HR)和95%可信区间(CI)。926例和714例患者分别进入了诊断前和诊断后看电视的分析，其中471例和325例在随访中死亡。长时间看诊断前电视与结直肠癌特异性死亡率的风险增加有关，与休闲时间的体力活动无关。0-6、7-13、14-20和≥21h/wk的心率(95%顺式)分别为1.00(参照物)、0.84(0.56-1.25)、1.15(0.75-1.78)、2.13(1.31-3.45)(P趋势=0.01)。这种关联主要是在超重和肥胖的个人中观察到的。诊断前看电视也与诊断后5年内的总死亡率相关，这主要是由于与结直肠癌死亡率的相关性。其他诊断前坐在家里或上班/开车与死亡率无关。诊断后看电视与诊断前看电视调整后的结直肠癌特异性死亡率(≥21的HR为0-6小时/周=1.45；95%可信区间为0.73-2.87)无显著相关。在结直肠癌患者中，诊断前长时间看电视与较高的结直肠癌特异性死亡率相关，与休闲时间的体力活动无关。
To assess the association between pre- and postdiagnostic time spent sitting watching TV as well as other sedentary behaviors (other sitting at home and at work/driving) and mortality from colorectal cancer or other causes, and overall mortality. We followed stage I-III colorectal cancer patients from the Health Professionals Follow-up Study (1986–2010). Cox models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). 926 and 714 patients were included in the analysis of pre- and postdiagnostic TV watching respectively, and 471 and 325 died during follow-up. Prolonged prediagnostic TV viewing was associated with increased risk of colorectal cancer-specific mortality independent of leisure-time physical activity. The HRs (95% CIs) for 0–6, 7–13,14–20 and ≥21 h/wk were 1.00 (referent), 0.84 (0.56–1.25), 1.15 (0.75–1.78), 2.13 (1.31–3.45) (Ptrend=0.01). The association was observed primarily among overweight and obese individuals. Prediagnostic TV watching was also associated with overall mortality within 5 years of diagnosis, largely due to the association with colorectal cancer mortality. Other prediagnostic sitting at home or at work/driving was not associated with mortality. Postdiagnostic TV viewing was associated with non-significant increased risk of colorectal cancer-specific mortality (HR for ≥21 vs 0–6 h/wk=1.45; 95% CI 0.73–2.87) adjusting for TV viewing before diagnosis. Prolonged prediagnostic TV watching is associated with higher colorectal cancer-specific mortality independent of leisure-time physical activity among colorectal cancer patients.